| Project/Area Number |
16K15384
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Osaka Medical College |
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Principal Investigator |
TAMAKI Junko 大阪医科大学, 医学部, 教授 (90326356)
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| Co-Investigator(Kenkyū-buntansha) |
伊木 雅之 近畿大学, 医学部, 教授 (50184388)
梶田 悦子 名古屋大学, 医学系研究科(保健), 教授 (50135373)
新田 明美 大阪医科大学, 医学部, 助教 (00737744)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | スクレロスチン / 骨血管相関 / 動脈硬化 |
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| Outline of Final Research Achievements |
We investigated the relationship of serum sclerositn levels to vascular calcification events at caroid artery using 290 women longitudinally. Serum sclerositn levels were measured using frozen serum obtained in the 15-year follow-up survey. The number of vascular calcification events which occurred during the 10-year and 20-year follow-up survey was twenty-seven. The event rates of the lowest, middle, highest tertile of sclerostin levels were 10.4%, 10.3%, 7.2%, respectively (p-value for trend test=0.446). Odds ratio of 1SD increase in log-transformed sclerositn for vascular calcification events neither indicated statistical significance (Odds ratio, 1.00, p-value of 0.988).
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