Are high serum sclerostin levels, bone formation inhibitory factor, associated with a decreased risk of vascular calcification? A long term cohort study for Multi-organ association

• Project/Area Number: 16K15384
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Osaka Medical College
• Principal Investigator: TAMAKI Junko 大阪医科大学, 医学部, 教授 (90326356)
• Co-Investigator(Kenkyū-buntansha): 伊木 雅之 近畿大学, 医学部, 教授 (50184388) ; 梶田 悦子 名古屋大学, 医学系研究科(保健), 教授 (50135373) ; 新田 明美 大阪医科大学, 医学部, 助教 (00737744)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: スクレロスチン / 骨血管相関 / 動脈硬化

Outline of Final Research Achievements

We investigated the relationship of serum sclerositn levels to vascular calcification events at caroid artery using 290 women longitudinally. Serum sclerositn levels were measured using frozen serum obtained in the 15-year follow-up survey. The number of vascular calcification events which occurred during the 10-year and 20-year follow-up survey was twenty-seven. The event rates of the lowest, middle, highest tertile of sclerostin levels were 10.4%, 10.3%, 7.2%, respectively (p-value for trend test=0.446). Odds ratio of 1SD increase in log-transformed sclerositn for vascular calcification events neither indicated statistical significance (Odds ratio, 1.00, p-value of 0.988).

Research Products

• [Journal Article] Total 25-hydroxyvitamin D levels predict fracture risk: Results from the 15-year follow-up of the Japanese Population-based Osteoporosis (JPOS) Cohort Study. (2017)
  • Author(s): Tamaki J, Iki M, Sato Y, Kajita E, Nishino H, Akiba T, Matsumoto T, Kagamimori S
  • Journal Title: Osteoporosis International Volume: E-pub Pages: 1903-1913
  • DOI: 10.1007/s00198-017-3967-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 低骨密度は上腕 足首脈波伝播速度を速めるか JPOSコホート研究による縦断的検討 (2016)
  • Author(s): 玉置 淳子, 小松 美砂, 梶田 悦子, 新井 清美, Dongmei Namiraa, 佐藤 裕保, 甲田 勝康, 立木 隆広, 新田 明美, 池原 賢代, 臼田 寛, 伊木 雅之, 鏡森 定信, 香川 芳子, 米島 秀夫
  • Organizer: 第75回日本公衆衛生学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2016-10-26
• [Presentation] 上腕-足首脈波伝播速度値は脆弱性骨折リスクと関連する-the Japanese Population-Based Osteoporosis(JPOS)Cohort Study (2016)
  • Author(s): 玉置 淳子, 伊木 雅之, 梶田 悦子, 小松 美砂, 立木 隆広, 新田 明美, 甲田 勝康, 臼田 寛, 由良 晶子, 佐藤 裕歩, 濱田 昌実, 池原 賢代, 鏡森 定信, 香川 芳子, 米島 秀夫
  • Organizer: 第34回日本骨代謝学会学術集会、第3回アジア太平洋骨代謝学会議
  • Place of Presentation: 大阪
  • Year and Date: 2016-07-20
• [Remarks] 近畿大学医学部公衆衛生学ホームページ
  • URL: http://www.med.kindai.ac.jp/pubheal/jpos/Results.html