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Integrated analysis of postmortem CT and genetic polymorphism for personal features and diseases

Research Project

Project/Area Number 16K15403
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Legal medicine
Research InstitutionShimane University

Principal Investigator

Takeshita Haruo  島根大学, 医学部, 教授 (90292599)

Research Collaborator FUJIHARA Junko  
KIMURA-KATAOKA Kaori  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords死後画像データ / 身長関連遺伝子多型マーカー / 遺伝子多型 / 死後画像診断
Outline of Final Research Achievements

In recent years, there is an increased activity of incorporating postmortem imaging into the social system, and new medical information is being accumulated. We investigated the relationship between single nucleotide polymorphism (SNP) and physical features from postmortem CT plus data from forensic autopsies.
HMGA2 gene is involved in embryonic growth and it has been reported to be associated with Caucasian height. We analyzed 3 SNPs within HMGA2 and only rs7968902 was significantly associated with Japanese height. Next, we investigated the relationship between SNP within GHR gene and organ weights. The rs6180 C allele is associated with the increased heart weight, left ventricular weight, heart hypertrophic coefficient, body surface area, right lung weight, and kidney weights. In addition, we examined the relationship between SNP within ERAP1 gene and organ weight, and found that cerebral weight with rs27434 SNP in both males and females.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 4 results) Presentation (6 results)

  • [Journal Article] Simple screening method for copy number variations associated with physical features2017

    • Author(s)
      M Ueki, H Takeshita, J Fujihara, K Kimura-Kataoka, R Iida, T Yasuda
    • Journal Title

      Legal Med

      Volume: 25 Pages: 71-74

    • DOI

      10.1016/j.legalmed.2017.01.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association of a single-nucleotide polymorphism (rs6180) in GHR gene with plural tissue weight2016

    • Author(s)
      Fujihara J, Kimura-Kataoka K, Yasuda T, Sano R, Kominato Y, Takeshita H
    • Journal Title

      J Genet

      Volume: 95 Pages: 189-192

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Association of XRCC1 polymorphisms with arsenic methylation2016

    • Author(s)
      Fujihara J, Yasuda T, Iwata H, Tanabe S, Takeshita H
    • Journal Title

      Arch Toxiocol

      Volume: 90 Pages: 1009-1012

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Whole brain analysis of postmortem density changes of grey and white matter on computed tomography by statistical parametric mapping2016

    • Author(s)
      Nishiyama Y, Kanayama H, Mori H, Tada K, Yamamoto Y, Katsube T, Takeshita H, Kawakami K, Kitagaki H
    • Journal Title

      Eur Radiol

      Volume: - Issue: 6 Pages: 2317-2325

    • DOI

      10.1007/s00330-016-4633-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 心疾患患者における血清中cell-free DNAに関する予備的検討.2017

    • Author(s)
      藤原純子,瀧波慶和,竹下治男,木村かおり,安田年博,倉田さつき.
    • Organizer
      DNA多型学会 第26回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Endoplasmic reticulum aminopeptidase 1(ERAP1)遺伝子におけるSNP(rs27434)と臓器重量等との関連.2017

    • Author(s)
      山田和夫,藤原純子,竹下治男,木村かおり,安田年博.
    • Organizer
      DNA多型学会 第26回学術集会.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血中ZnおよびFe濃度に関与する遺伝子多型部位の予備的探索.2017

    • Author(s)
      藤原純子,木村かおり,竹下治男,倉田さつき,安田年博.
    • Organizer
      第101次日本法医学会学術全国集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト年齢依存性生体分子M-LPHの機能解析2016

    • Author(s)
      安田年博,飯田礼子,植木美鈴,竹下治男,小湊慶彦
    • Organizer
      第100次日本法医学会学術全国集会
    • Place of Presentation
      東京(きゅりあん 品川区立総合区民会館)
    • Related Report
      2016 Research-status Report
  • [Presentation] 島根大学法医解剖における医療行為関連事案紹介および今後の医療事故調査制度へのAiや病理解剖施行について2016

    • Author(s)
      木村かおり,竹下治男,藤原純子,金山秀和,北垣一,丸山理留敬
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台(仙台国際センター)
    • Related Report
      2016 Research-status Report
  • [Presentation] ポータブルラマン分光器を用いた非破壊の血痕検査法と人獣鑑別法の確立2016

    • Author(s)
      藤原純子,竹下治男,木村かおり,藤田恭久,安田年博,倉田さつき
    • Organizer
      DNA多型学会 第25回学術集会
    • Place of Presentation
      千葉(東京大学 大気海洋研究所)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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