| Project/Area Number |
16K15404
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
Ohta Shigeru 広島大学, 医歯薬保健学研究科(薬), 教授 (60160503)
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| Co-Investigator(Kenkyū-buntansha) |
奥田 勝博 旭川医科大学, 医学部, 助教 (00389115)
佐能 正剛 広島大学, 医歯薬保健学研究科(薬), 助教 (00552267)
古武 弥一郎 広島大学, 医歯薬保健学研究科(薬), 准教授 (20335649)
清水 惠子 旭川医科大学, 医学部, 教授 (90312462)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 薬毒物 / 毒性 / 代謝 / 心筋細胞 / 神経細胞 / 肝細胞 / スフェロイド / 薬物動態 |
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| Outline of Final Research Achievements |
The main causes of poisoned to death by toxic chemicals are consciousness disorder, convulsions, arrhythmia and heart failure. Therefore, it is necessary to consider toxicity mechanism in the brain and the heart. Moreover, it is also necessary to consider the contribution of the metabolites formed in the liver to toxicity. In this study, we have constructed an in vitro toxicity evaluation system that reflected the in vivo function, such as three-dimensional culture system using myocardial cells, neurons, and hepatocytes, and have studied the toxicity mechanism of toxic chemicals.
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