The role of residual dendritic cell in the early phase of atherosclerosis
| Project/Area Number |
16K15439
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大坂 瑞子 東京医科歯科大学, 統合研究機構, 助教 (00581711)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 血管炎症 / 高脂肪食 / 白血球接着 / 白血球集積 / 内在性白血球 / 内皮下浸潤 / 白血球 / 循環器 / 免疫学 |
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| Outline of Final Research Achievements |
We examined to observe the process of leukocyte migration via adhesion on murine femoral artery in parabiosis model under high fat diet feeding. Although leukocyte accumulation was captured in intima, migration via adhesion was not seen. Thus, these results suggested that increase of residual leukocyte in intima may induce leukocyte accumulation but not migration. In addition, inhibition of leukocyte adhesion decreased leukocyte accumulation in intima suggesting that leukocyte adhesion may related in increase of residual leukocytes.
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Report
(3 results)
Research Products
(9 results)
