| Project/Area Number |
16K15455
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SHIBUYA Akira 筑波大学, 生命領域学際研究センター, 教授 (80216027)
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 喘息 |
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| Outline of Final Research Achievements |
Bronchial asthma is characterized by reversible bronchial obstruction, airway inflammation and airway hypersensitivity. Since some patients with this disease show resistance to the steroid therapy, the development of a new therapy for this disease is being expected. In this study, we aimed to clarify the effect of PC-liposome on airway hypersensitivity to methacholine. Mice that were treated i.n. with PC-liposome for 5 days 3 weeks after the start of induction of allergic asthma by HDM treatment showed amelioration of the airway hypersensitivity. Those mice treated with PC-liposome for 10 days 2 weeks after the start of induction of allergic asthma by HDM treatment showed no airway hypersensitivity. These results suggest a possibility that the therapy by PC-liposome is useful for the allergic asthma.
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