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Regulation of small cell lung carcinoma cells by interference between axon guidance molecules and their receptors

Research Project

Project/Area Number 16K15459
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionKumamoto University

Principal Investigator

Ito Takaaki  熊本大学, 大学院生命科学研究部(医), 教授 (70168392)

Co-Investigator(Renkei-kenkyūsha) MATSUO Akira  熊本大学, 大学院生命科学研究部, 研究員 (50735074)
SHINMYO Yohei  金沢大学, 医学保健研究域医学系, 准教授 (00418831)
HASEGAWA Koki  京都薬科大学, 薬学部, 准教授 (50525798)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords小細胞肺癌 / 非小細胞肺癌 / Draxin / Netrin1 / Neogenin / DCC / draxin / neterin1 / neogenin / ガイダンス分子 / 受容体 / 癌 / 神経ガイダンス分子 / 分子標的治療
Outline of Final Research Achievements

The axon guidance molecule-receptor system works not only in neural network formation, and but also in cancer cell proliferation and apoptosis. Draxin and Netrin1 share their receipt, DCC and Neogenin. This study was done to elucidate the significance of the guidance molecule-receptor system in lung cancer cell proliferation and survival. Western blotting and immunohistochemical studies revealed that small cell lung cancer and non-small cell lung cancer express these molecules. Though gene knockdown and over-expression studies using small cell lung cancer cell lines, using non-small cell lung cancer cell lines, we demonstrated that the system works in lung cancer cell proliferation and survival. And, it is suggested that Draxin could interact directly with Netrin1 in cancer cell proliferation.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Expression of Draxin in Lung Carcinomas2018

    • Author(s)
      Sato Y, Matsuo A, Kudoh S, Liu F, Hasegawa K, Shinmyo Y, Ito T
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 51 Issue: 1 Pages: 53-62

    • DOI

      10.1267/ahc.17035

    • NAID

      130006405032

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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