| Project/Area Number |
16K15487
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Iwabu Miki 東京大学, 医学部附属病院, 特任准教授 (70392529)
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| Co-Investigator(Renkei-kenkyūsha) |
IWABU Masato 東京大学, 医学部附属病院, 特任准教授 (30557236)
YAMAUCHI Toshimasa 東京大学, 医学部附属病院, 准教授 (40372370)
KADOWAKI Takashi 東京大学, 医学部附属病院, 教授 (30185889)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 糖尿病 / 食品 / 農林水産物 / 生体機能利用 |
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| Outline of Final Research Achievements |
The aim of this research was to generate scientific evidence for vegetables, fruits and their processed products that may serve as a basis for developing next-generation functional foods directed toward promoting adiponectin/AdipoR action, thereby establishing novel preventive measures against lifestyle-related diseases. In this research, vegetable ingredients/functional substances with lifestyle-related disease-counteractive properties were identified in experiments using cultured cells. Again, all identified vegetable ingredients/functional substances were examined for their glucose-lowering properties in animal models of lifestyle-related diseases (in preparation). Furthermore, these vegetable ingredients/functional substances were examined for their acute and chronic toxicity profile to explore their potential for product development.
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