Anti-lymphoma therapy targeting cholesterol metabolism
| Project/Area Number |
16K15503
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
哈 斯塔 (Horlad Hasita) 熊本大学, 大学院生命科学研究部(医), 研究員 (00644840)
藤原 章雄 熊本大学, 大学院生命科学研究部(医), 講師 (70452886)
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| Co-Investigator(Renkei-kenkyūsha) |
Matsuoka Masao 熊本大学, 大学院生命科学研究部, 教授 (10244138)
Okuno Yutaka 熊本大学, 大学院生命科学研究部, 准教授 (80363539)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | リンパ腫 / コレステロール / 白血病 / 治療 |
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| Outline of Final Research Achievements |
We investigated if cholesterol metabolism would be important for cell growth in cell lines derived from malignant lymphoma and leukemia. As the result of studies, cholesterol metabolism is critical for cell growth in lymphoma and leukemia cells. Blocking of cholesterol efflux was also found to be important for cell growth, and blocking for cholesterol efflux induced apoptosis of lymphoma and leukemia cells.
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Report
(3 results)
Research Products
(4 results)
