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Anti-lymphoma therapy targeting cholesterol metabolism

Research Project

Project/Area Number 16K15503
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionKumamoto University

Principal Investigator

Komohara Yoshihiro  熊本大学, 大学院生命科学研究部(医), 准教授 (40449921)

Co-Investigator(Kenkyū-buntansha) 哈 斯塔 (Horlad Hasita)  熊本大学, 大学院生命科学研究部(医), 研究員 (00644840)
藤原 章雄  熊本大学, 大学院生命科学研究部(医), 講師 (70452886)
Co-Investigator(Renkei-kenkyūsha) Matsuoka Masao  熊本大学, 大学院生命科学研究部, 教授 (10244138)
Okuno Yutaka  熊本大学, 大学院生命科学研究部, 准教授 (80363539)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsリンパ腫 / コレステロール / 白血病 / 治療
Outline of Final Research Achievements

We investigated if cholesterol metabolism would be important for cell growth in cell lines derived from malignant lymphoma and leukemia. As the result of studies, cholesterol metabolism is critical for cell growth in lymphoma and leukemia cells. Blocking of cholesterol efflux was also found to be important for cell growth, and blocking for cholesterol efflux induced apoptosis of lymphoma and leukemia cells.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] コレステロール代謝経路攪乱による新しい白血病・リンパ腫治療2017

    • Author(s)
      菰原義弘、藤原章雄
    • Journal Title

      Bio Clinica

      Volume: 32 Pages: 80-81

    • Related Report
      2017 Annual Research Report
  • [Journal Article] コレステロール排出経路阻害による新しい白血病・リンパ腫治療.2017

    • Author(s)
      菰原義弘、藤原章雄
    • Journal Title

      メディカル・サイエンス・ダイジェスト

      Volume: 43 Pages: 378-379

    • Related Report
      2017 Annual Research Report
  • [Presentation] Inhibitory effect on Lymphoma Cell Proliferation by Regulating Cholesterol Metabolism Pathway2016

    • Author(s)
      Yukio Fujiwara, Hasita Horlad, Daisuke Niino, Yutaka Okuno, Kikukawa Yoshitaka, Masao Matsuoka, Motohiro Takeya, Yoshihiro Komohara,
    • Organizer
      THE 1ST MEETING OF THE YONGLIN HEALTHCARE SYMPOSIUM SERIES-“DNA PROCESSES, DRUGS AND CANCER”
    • Place of Presentation
      台湾
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] コレステロール排出経路を標的とした新たながん治療戦略2016

    • Author(s)
      菰原義弘、藤原章雄、Horlad Hasita 、矢野浩夢、潘程、竹屋元裕
    • Organizer
      第48回日本臨床分子形態学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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