| Project/Area Number |
16K15533
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Kato Motohiro 国立研究開発法人国立成育医療研究センター, 小児血液・腫瘍研究部, 医長 (40708690)
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| Co-Investigator(Renkei-kenkyūsha) |
Yoshida Masanori 国立成育医療研究センター, 小児血液・腫瘍研究部, 臨床研究員
Shirai Ryota 国立成育医療研究センター, 小児血液・腫瘍研究部, 臨床研究員
Osumi Tomoo 国立成育医療研究センター, 小児血液・腫瘍研究部, 臨床研究員
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌 |
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| Outline of Final Research Achievements |
Secondary malignant neoplasms (SMNs) are one of the most important late complication in the treatment of pediatric malignancies. Recently, higher prevalence of germline mutation in cancer-predisposition genes in children with SMNs compared to that in non-cancer population have been reported.
Here, we investigated the frequency of genetic mutation in 162 cancer-predisposition genes in 27 cases who suffered SMNs with whole exome sequencing. Germline variants were detected in 5 of the 27 (18.2%) cases with SMNs, and the frequency was higher than that of control cohorts (3 of 104 cases [2.8%]).
Germline cancer predisposition affects susceptibility to SMNs in cases with pediatric cancer.
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