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Pathogenesis of bullous pemphigoid: a study using class-switched monoclonal antibodies.

Research Project

Project/Area Number 16K15539
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

Nishie Wataru  北海道大学, 医学研究科, 准教授 (20443955)

Co-Investigator(Kenkyū-buntansha) 夏賀 健  北海道大学, 大学病院, 講師 (70645457)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords皮膚病態学 / 皮膚病態斈
Outline of Final Research Achievements

Bullous pemphigoid (BP) is an autoimmune blistering skin disease, in which autoantibodies target collagen XVII (COL17) in the skin. Here we produced recombinant monoclonal antibodies (mAb) directing COL17 with different isotypes including IgG1, IgG2a, IgA and IgE. These mAbs have identical variable regions. Passive transfer of these mAbs into mice induced activation of complements when IgG2a but not IgG1 mAbs were injected. However, there was no clinical differences were observed in complement-activating and complement-non-activating recipient mice. These results suggest that activation of complements is not enough to induce blistering skin disease in mice.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] C-Terminal Processing of Collagen XVII Induces Neoepitopes for Linear IgA Dermatosis Autoantibodies2017

    • Author(s)
      Toyonaga Ellen、Nishie Wataru、Izumi Kentaro、Natsuga Ken、Ujiie Hideyuki、Iwata Hiroaki、Yamagami Jun、Hirako Yoshiaki、Sawamura Daisuke、Fujimoto Wataru、Shimizu Hiroshi
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 137 Issue: 12 Pages: 2552-2559

    • DOI

      10.1016/j.jid.2017.07.831

    • NAID

      120006540048

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of mucous membrane pemphigoid autoantibodies by full-length BP180 enzyme-linked immunosorbent assay2017

    • Author(s)
      Izumi Kentaro、Nishie Wataru、Mai Yosuke、Ujiie Hideyuki、Iwata Hiroaki、Natsuga Ken、Shimizu Hiroshi
    • Journal Title

      J Dermatol Sci

      Volume: 88 Issue: 2 Pages: 247-248

    • DOI

      10.1016/j.jdermsci.2017.07.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid.2016

    • Author(s)
      Izumi K, Nishie W, Mai Y, Wada M, Natsuga K, Ujiie H, Iwata H, Yamagami J, Shimizu H
    • Journal Title

      J Invest Dermatol

      Volume: 136 Issue: 11 Pages: 2201-2210

    • DOI

      10.1016/j.jid.2016.06.622

    • NAID

      120006360054

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Fc-independent mechanisms.2017

    • Author(s)
      Nishie W
    • Organizer
      Scientific conference of the International Pemphigus and Pemphigoid Foundation (IPPF)、リューベック.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Immunopathological variants of bullous pemphigoid.2016

    • Author(s)
      Nishie W.
    • Organizer
      Symposium to the 46th ESDR meeting
    • Place of Presentation
      Institute of Anatomy and Cell Biology, Munich, Germany
    • Year and Date
      2016-09-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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