| Project/Area Number |
16K15542
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
土山 健一郎 東北大学, 大学病院, 助教 (50711743)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 色素細胞 / 自然免疫 / トール様受容体 / Rab GTPase / Toll様受容体 / RAB / 色素産生 / 膜輸送 / メラニン / メラノソーム |
|---|
| Outline of Final Research Achievements |
We examined the influence of melanosome / melanin synthesis and transport mechanism of pigment cells by the innate immune msystem. The stimulation of cultured melanocytes with the innate immune activating factor (TLRs stimulating factors) and the release of melanin / melanosome showed that melanosome release increased with TLR3 ligands. Stimulation of TLR3 ligands activated the melanosome / melanin transport pathway without increasing the melanin production-related gene, and the activation of this transport pathway is mainly responsible for the production of Rab, a membrane-associated GTPase, RAB 27A. We reported the paper in Pigment Cell and Melanoma Research (2018 e-published).
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