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Therapy for dementia by free electron laser irradiation

Research Project

Project/Area Number 16K15553
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionGunma University

Principal Investigator

NAKAMURA KAZUHIRO  群馬大学, 大学院保健学研究科, 教授 (10327835)

Co-Investigator(Kenkyū-buntansha) 川崎 平康  東京理科大学, 研究推進機構総合研究院, 研究員 (00363268)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords赤外自由電子レーザー / 中赤外光 / 中赤外自由電子レーザー
Outline of Final Research Achievements

Alzheimer's disease is a devastating neurodegenerative disorder, for which effective treatments have not been explored. Previously, I reported that aggregated amyloid beta 1-42 peptide was dissociated by free electron laser irradiation. In this study, I studied if that is also the case for autopsy brain from Alzheimer-type dementia. I applied mid infrared light to frontal cortex blocks from the 4 cases. Then, I carried out western blot analysis. The signal pattern of high molecular weight form of amyloid beta rather than the monomer form was changed after the irradiation only in part of the cases. However, it is not known if the toxic form of amyloid beta was decreased after irradiation. I will continue the reaearch by analysing neurological functions of the brain after irradiation.

Academic Significance and Societal Importance of the Research Achievements

ペプチドレベルでは、アミロイドベータ以外の他の複数の凝集体たんぱくが中赤外光によって解離を示している。現在までのウェスタンブロットを用いた解析では、アルツハイマー型認知症剖検脳におけるアミロイドベータの内、毒性を有する構造体を減少させたかどうかは不明である。しかし、今後の神経機能の解析によって、照射後の神経機能回復を示すデータが得られた場合には、この方法はアルツハイマー型認知症以外の他のアミロイドーシスの組織の機能改善効果が期待できる方法となり得る可能性を有する。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Dissociation of β-Sheet Stacking of Amyloid β Fibrils by Irradiation of Intense, Short-Pulsed Mid-infrared Laser.2018

    • Author(s)
      Kawasaki T, Yaji T, Ohta T, Tsukiyama K, Nakamura K.
    • Journal Title

      Cell Mol Neurobiol.

      Volume: in press Issue: 5 Pages: 1039-1049

    • DOI

      10.1007/s10571-018-0575-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Targeting beta-sheet stacking of Alzheimer’s amyloid beta peptide by mid-infrared free-electron laser2018

    • Author(s)
      Takayasu Kawasaki, Toyonari Yaji, Toshiaki Ohta, Koichi Tsukiyama, Kazuhiro Nakamura
    • Organizer
      Alzheimers Research UK conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 赤外自由電子レーザーの神経変性疾患治療への応用2016

    • Author(s)
      中村和裕
    • Organizer
      第63回北関東医学会総会特別講演
    • Place of Presentation
      群馬大学医学部刀城会館
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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