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Surrogate imaging of micrometastases in sentinel lymph nodes based on immune reactions

Research Project

Project/Area Number 16K15587
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNational Cancer Center Japan

Principal Investigator

FUJII HIROFUMI  国立研究開発法人国立がん研究センター, 先端医療開発センター, 分野長 (80218982)

Research Collaborator Ohnuki Kazunobu  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsセンチネルリンパ節 / 画像診断 / 免疫応答 / 低侵襲 / 転移モデル / 胚中心 / 微小転移 / イメージング / 小転移病巣 / サロゲートイメージング / がん / 転移 / 免疫
Outline of Final Research Achievements

We investigated methods to in vivo visualize micrometastases in sentinel lymph nodes (SNs) by observing immune reactions in non-tumor areas of SNs. This indirect visualization method would be “surrogate imaging” in the diagnosis of metastatic status of SNs. Our non-clinical experiments with mouse models injected tumor cells in their foot pads demonstrated that lymph follicles and germinal centers, which were composed of B lymphocytes, increased before the appearance of metastatic foci in SNs. High magnetic field MR imaging tests had a potential to visualize these interiors of SNs.

Academic Significance and Societal Importance of the Research Achievements

センチネルリンパ節内の微小転移病巣をインビボで可視化することができれば、センチネルリンパ節生検を省略して、所属リンパ節の転移状態を知ることが可能となり、究極の低侵襲がん治療が実現する。がん患者は生検の負担がなくなり、術者は生検の手間を省くことができ、術中病理迅速診断の待ち時間がなくなり手術時間の短縮につながる。こうした手術法の簡素化は、医療資源の節約となり、医療削減にもつながるため、社会的にも意義深いものと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017 2016

All Presentation (13 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results) Book (2 results)

  • [Presentation] マウスモデルを用いたセンチネルリンパ節内免疫反応の経時的解析2018

    • Author(s)
      大貫和信, 藤井博史
    • Organizer
      第18回 SNNS研究会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Imaging of sentinel lymph nodes2018

    • Author(s)
      Hirofumi Fujii, Kazunobu Ohnuki
    • Organizer
      2017 International Biomedical Interface Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] センチネルリンパ節内転移診断に向けたイメージング技術の開発2018

    • Author(s)
      大貫和信, 藤井博史
    • Organizer
      第12回日本分子イメージング学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Longitudinal analysis of the immune cells in the sentinel lymph node in a mouse model: possibility of the application toward an imaging diagnostic technology2018

    • Author(s)
      Kazunobu Ohnuki, Hirofumi Fujii
    • Organizer
      International Symposium on Imaging Frontier 2017 (ISIF 2017)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] センチネルリンパ節内転移診断と予後予測に向けたイメージング技術の開発2018

    • Author(s)
      大貫和信, 藤井博史
    • Organizer
      日本分子イメージング学会第13回総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] センチネルリンパ節イメージングのこれまでとこれから2018

    • Author(s)
      藤井博史
    • Organizer
      第20回SNNS研究会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] マウスモデルにおけるセンチネルリンパ節内の免疫反応の経時的変化2018

    • Author(s)
      藤井博史, 大貫和信
    • Organizer
      第20回SNNS研究会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] センチネルリンパ節内小転移病巣診断のための早期免疫反応の可視化技術の検討2018

    • Author(s)
      大貫和信, 山口雅之, 藤井博史
    • Organizer
      第20回SNNS研究会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Longitudinal evaluation of immunological reactions in sentinel lymph nodes of mouse models2018

    • Author(s)
      Hirofumi Fujii, Kazunobu Ohnuki
    • Organizer
      International Sentinel Node Society 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The imaging strategy for the early immune response to predict the metastatic status of SLNs2018

    • Author(s)
      Kazunobu Ohnuki, Masayuki Yamaguchi, Hirofumi Fujii
    • Organizer
      International Sentinel Node Society 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] センチネルリンパ節内転移診断に向けたイメージング技術の開発2017

    • Author(s)
      大貫和信, 藤井博史
    • Organizer
      第12回日本分子イメージング学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Longitudinal analysis of the immune cells in the sentinel lymph node in a mouse model: possibility of the application toward an imaging diagnostic technology2017

    • Author(s)
      Kazunobu Onuki, Hirofumi Fujii
    • Organizer
      International Symposium on Imaging Frontier 2017(ISIF 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウスモデルを用いたセンチネルリンパ節内免疫反応の経時的解析2016

    • Author(s)
      大貫和信, 藤井博史
    • Organizer
      第18回 SNNS研究会学術集会
    • Place of Presentation
      東京都品川区品川シーズンテラスカンファレンス
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
  • [Book] Lymph Node Metastasis in Gastrointestinal Cancer2019

    • Author(s)
      Ohnuki K, Fujii H
    • Total Pages
      358
    • Publisher
      Springer
    • ISBN
      9789811046995
    • Related Report
      2018 Annual Research Report
  • [Book] Lymph Node Metastasis in Gastrointestinal Cancer2017

    • Author(s)
      Kasunobu Ohnuki, Hirofumi Fujii
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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