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Development of a sensitive detection method for pancreatic cancer patients with serum based on a new concept

Research Project

Project/Area Number 16K15613
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyoto University

Principal Investigator

Uemoto Shinji  京都大学, 医学研究科, 教授 (40252449)

Co-Investigator(Kenkyū-buntansha) 増井 俊彦  京都大学, 医学研究科, 講師 (20452352)
平川 慶子  日本医科大学, 医学部, 助教 (30165162)
小池 薫  京都大学, 医学研究科, 教授 (10267164)
佐藤 格夫  京都大学, 医学研究科, 准教授 (30409205)
柚木 知之  京都大学, 医学研究科, 助教 (50639094)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsNMR / 振動解析 / 膵癌 / 胆管癌 / 早期発見 / 肝癌 / バイオマーカー / 核磁気共鳴法 / パターン認識 / 血清 / 早期診断
Outline of Final Research Achievements

We applied a new serum method incorporated "a technique of vibration analysis to evaluate the dynamic characteristics of structures" to pancreatic cancer patients and to cholangiocarcinoma patients. First, a group of 46 curatively resected cases of pancreatic cancer patients from 2013 to 2016 were analyzed in contrast to a group included 34 non-cancer patients of the same age. We collected preoperative serum performed vibration analysis using NMR. This new serum test was able to isolate pancreatic cancer patients from non-cancer patients. Furthermore, it was possible to separate 20 pancreatic cancer patients with early recurrence from 26 patients with late recurrence, which could be used for prediction of early recurrence. When we applied this method to cholangiocarcinoma and liver cancer, this method discriminated extrahepatic cholangiocarcinoma, intrahepatic cholangiocarcinoma and hepatoma, suggesting that the vibrational profile of NMR is different among each type of carcinoma.

Academic Significance and Societal Importance of the Research Achievements

本研究において血清による膵癌患者同定が可能であったことは、これまでの血清マーカーに加えて、我々の「構造物の動的特性を評価する振動解析の技法」が臨床的にも適用可能な新たな手法である可能性が示唆された。さらに、腫瘍の出しているマーカーのみならず腫瘍があることの体の反応全体を計測する本手法を洗練することにより、現在行われている腫瘍マーカーよりも早期の診断が可能となり、新たなスクリーニング検査となり得る可能性を秘めている。また、予後予測、また肝胆道系がんの分別が可能であることから、手術後の補助化学療法の適応、さらには再発のフォローアップ、病理組織でも診断困難な症例においても原発組織の推定が可能となる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (1 results)

  • [Journal Article] Short-time Fourier Transform of Free Induction Decays for the Analysis of Serum Using Proton Nuclear Magnetic Resonance2019

    • Author(s)
      Hirakawa Keiko、Koike Kaoru、Kanawaku Yoshimasa、Moriyama Tsuyoshi、Sato Norio、Suzuki Takao、Furihata Kenichi、Ohno Youkichi
    • Journal Title

      Journal of Oleo Science

      Volume: 68 Issue: 4 Pages: 369-378

    • DOI

      10.5650/jos.ess18212

    • NAID

      130007621685

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.2018

    • Author(s)
      Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H.
    • Journal Title

      J Clin Invest.

      Volume: 128 Issue: 8 Pages: 3475-3489

    • DOI

      10.1172/jci94287

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.2018

    • Author(s)
      Ikuta K, Fukuda A, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Tsuda M, Kimura Y, Matsumoto Y, Kimura Y, Maruno T, Kanda K, Nishi K, Takaori K, Uemoto S, Takaishi S, Chiba T, Nishi E, Seno H.
    • Journal Title

      Gut

      Volume: 印刷中 Issue: 5 Pages: 882-892

    • DOI

      10.1136/gutjnl-2017-315425

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 外科診療における遺伝学的検査の意義 7.肝胆膵2018

    • Author(s)
      増井俊彦、高折恭一、岡島英明、穴澤貴行、上本伸二
    • Journal Title

      日本外科学会雑誌 第119巻 第2号180-185

      Volume: 119 Pages: 180-185

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Prospective Study of Intensity-modified Radiation Therapy in Comparison with Conventional 3D-RT for BR Pancreatic Cancer Patients with Arterial Involvement.2017

    • Author(s)
      Masui T, Takaori K, Anazawa T, Sato A, Nakano K, Uchida Y, Yogo A, Goto Y, Matsumoto S, Kodama Y, Kanai M, Isoda H, Mizumoto M, Kawaguchi Y, Shibuya K, Itasaka S, Uemoto S.
    • Journal Title

      Anticancer Res.

      Volume: 37 Pages: 7023-7030

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] The appropriate target and timing of salvage surgery for locally advanced unresectable pancreatic cancer2017

    • Author(s)
      増井俊彦、仲野健三、佐藤朝日、伊藤達雄、穴澤貴行、高折恭一、上本伸二
    • Organizer
      第72回消化器外科学会総会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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