Development of a sensitive detection method for pancreatic cancer patients with serum based on a new concept
| Project/Area Number |
16K15613
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
Uemoto Shinji 京都大学, 医学研究科, 教授 (40252449)
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| Co-Investigator(Kenkyū-buntansha) |
増井 俊彦 京都大学, 医学研究科, 講師 (20452352)
平川 慶子 日本医科大学, 医学部, 助教 (30165162)
小池 薫 京都大学, 医学研究科, 教授 (10267164)
佐藤 格夫 京都大学, 医学研究科, 准教授 (30409205)
柚木 知之 京都大学, 医学研究科, 助教 (50639094)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | NMR / 振動解析 / 膵癌 / 胆管癌 / 早期発見 / 肝癌 / バイオマーカー / 核磁気共鳴法 / パターン認識 / 血清 / 早期診断 |
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| Outline of Final Research Achievements |
We applied a new serum method incorporated "a technique of vibration analysis to evaluate the dynamic characteristics of structures" to pancreatic cancer patients and to cholangiocarcinoma patients. First, a group of 46 curatively resected cases of pancreatic cancer patients from 2013 to 2016 were analyzed in contrast to a group included 34 non-cancer patients of the same age. We collected preoperative serum performed vibration analysis using NMR. This new serum test was able to isolate pancreatic cancer patients from non-cancer patients. Furthermore, it was possible to separate 20 pancreatic cancer patients with early recurrence from 26 patients with late recurrence, which could be used for prediction of early recurrence. When we applied this method to cholangiocarcinoma and liver cancer, this method discriminated extrahepatic cholangiocarcinoma, intrahepatic cholangiocarcinoma and hepatoma, suggesting that the vibrational profile of NMR is different among each type of carcinoma.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究において血清による膵癌患者同定が可能であったことは、これまでの血清マーカーに加えて、我々の「構造物の動的特性を評価する振動解析の技法」が臨床的にも適用可能な新たな手法である可能性が示唆された。さらに、腫瘍の出しているマーカーのみならず腫瘍があることの体の反応全体を計測する本手法を洗練することにより、現在行われている腫瘍マーカーよりも早期の診断が可能となり、新たなスクリーニング検査となり得る可能性を秘めている。また、予後予測、また肝胆道系がんの分別が可能であることから、手術後の補助化学療法の適応、さらには再発のフォローアップ、病理組織でも診断困難な症例においても原発組織の推定が可能となる。
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.2018
Author(s)
Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H.
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Journal Title
J Clin Invest.
Volume: 128
Issue: 8
Pages: 3475-3489
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.2018
Author(s)
Ikuta K, Fukuda A, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Tsuda M, Kimura Y, Matsumoto Y, Kimura Y, Maruno T, Kanda K, Nishi K, Takaori K, Uemoto S, Takaishi S, Chiba T, Nishi E, Seno H.
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Journal Title
Gut
Volume: 印刷中
Issue: 5
Pages: 882-892
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] A Prospective Study of Intensity-modified Radiation Therapy in Comparison with Conventional 3D-RT for BR Pancreatic Cancer Patients with Arterial Involvement.2017
Author(s)
Masui T, Takaori K, Anazawa T, Sato A, Nakano K, Uchida Y, Yogo A, Goto Y, Matsumoto S, Kodama Y, Kanai M, Isoda H, Mizumoto M, Kawaguchi Y, Shibuya K, Itasaka S, Uemoto S.
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Journal Title
Anticancer Res.
Volume: 37
Pages: 7023-7030
Related Report
Peer Reviewed
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