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Elucidation of pathophysiology of iNPH by dynamics analysis of water molecule

Research Project

Project/Area Number 16K15643
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionNiigata University

Principal Investigator

Suzuki Yuji  新潟大学, 脳研究所, 准教授 (90529851)

Co-Investigator(Kenkyū-buntansha) 藤井 幸彦  新潟大学, 脳研究所, 教授 (40283014)
中村 亨弥  新潟大学, 研究推進機構, 助教 (70377208)
山田 謙一  新潟大学, 脳研究所, 准教授 (70436773)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsiNPH / 水PET / Glymphatic System / アクアポリン / 正常圧水頭症 / PET / 水動態 / glymphatic system / 特発性正常圧水頭症 / PET画像 / アクアポリンPET / 脳神経疾患 / 神経画像診断学 / PET
Outline of Final Research Achievements

The purpose of this study is to directly evaluate the dynamics of water molecules in CNS in idiopathic normal pressure hydrocephalus (iNPH) for elucidating the pathophysiology. In recent years, attention has focused on cerebrospinal fluid regulatory mechanisms via the Glymphatic System including Interstitial flow, which can also be called the lymphatic system of the brain for the production and absorption of cerebrospinal fluid. We analyze the dynamics of water molecules from the analysis method using PET that it is deeply involved in iNPH showed a clear reduction in cortex-to-ventricular flow, and shunt surgery proved to improve the flow.

Academic Significance and Societal Importance of the Research Achievements

今回の研究で、iNPHの病態に水の動態が大きく関与していることが示唆され、手術などの治療の効果判定や手術時期に関する重要な情報を得ることが期待できる。さらにこの結果は、従来の脈絡叢を中心とした髄液コントロールのメカニズム以外に、Glymphatic Systemによる脳髄液のコントロールシステムが存在することを示唆するものである。
今回我々が提唱した脳内の水の動態を観察可能とする新たなる解析方法は、今後更なる研究により、iNPHのみならずGlymphatic Systemが関与する様々な疾患の病態解明に繋がることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2019 2018 2017

All Journal Article (15 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Open Access: 9 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Developmental abnormalities of the brain exposed to childhood maltreatment detected by diffusion tensor imaging.2019

    • Author(s)
      Yamada K, Suzuki Y, Okuyama M, Watanabe M, Nakada T
    • Journal Title

      Neurological Research

      Volume: 41 Issue: 1 Pages: 19-25

    • DOI

      10.1080/01616412.2018.1522413

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing the Distribution of Matrix Metalloproteinases in Ischemic Brain Using In Vivo 19F-Magnetic Resonance Spectroscopic Imaging2019

    • Author(s)
      Huber Vincent J.、Igarashi Hironaka、Ueki Satoshi、Terumitsu-Tsujita Mika、Nito Chikako、Ohno Ken、Suzuki Yuji、Itoh Kosuke、Kwee Ingrid L.、Nakada Tsutomu
    • Journal Title

      Contrast Media & Molecular Imaging

      Volume: 2019 Pages: 1-8

    • DOI

      10.1155/2019/8908943

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A case of atraumatic tetanus developed initially with worsening headache in a woman regularly cared for chronic headache at an outpatient clinic2019

    • Author(s)
      Tobinaga Masanobu、Suzuki Yuji、Nakajima Takashi
    • Journal Title

      Clinical Case Reports

      Volume: 7 Issue: 3 Pages: 486-490

    • DOI

      10.1002/ccr3.2024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-related increase in GABAA receptor distribution in the prefrontal cortex2019

    • Author(s)
      Tobinaga Masanobu、Suzuki Yuji、Fujinaka Hidehiko、Ozawa Tetsuo、Nakajima Takashi
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: ー Pages: 106-110

    • DOI

      10.1016/j.jocn.2019.03.044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glymphatic systemの機能画像2019

    • Author(s)
      鈴木雄治
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 46-48

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 3DAC PROPELLER: An overly underused powerful MRI modality2018

    • Author(s)
      Nakada T, Suzuki K, Suzuki Y. Nakada K, Kwee IL
    • Journal Title

      Anatomy Physiol Biochem Int J

      Volume: 4 Pages: 555626-555626

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Advances and Challenges in Assessing 2-Hydroxyglutarate in Gliomas by Magnetic Resonance Spectroscopy: A Short Review.2018

    • Author(s)
      Natsumeda M, Igarashi H, Motohashi K, Suzuki Y, Ohkubo M, Okamoto K, Watanabe M, Nakada T, Fujii Y
    • Journal Title

      Neuropsychiatry

      Volume: 8 Pages: 1831-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aquaporin PET differentiates between grade III and IV human astrocytoma.2018

    • Author(s)
      Suzuki Y, Nakamura Y, Yamada K, Kurabe S, Okamoto K, Aoki H, Kitaura H, Kakita A, Fujii Y, Huber VJ, Igarashi H, Kwee IL, Nakada T
    • Journal Title

      Neurosurgery

      Volume: 印刷中 Issue: 6 Pages: 842-846

    • DOI

      10.1093/neuros/nyx314

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abnormal Distribution of GABAA Receptors in Brain of Duchenne Muscular Dystrophy Patients.2017

    • Author(s)
      Suzuki Y, Higuchi S, Aida I, Nakajima T, Nakada T
    • Journal Title

      Muscle Nerve

      Volume: Apr;55(4) Issue: 4 Pages: 591-595

    • DOI

      10.1002/mus.25383

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: a 1H-MR spectroscopy study.2017

    • Author(s)
      Shimizu M, Suzuki Y, Yamada K, Ueki S, Watanabe M, Igarashi H, Nakada T.
    • Journal Title

      Pediatr Res

      Volume: 82 Issue: 5 Pages: 749-752

    • DOI

      10.1038/pr.2017.101

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Magnetic Resonance Imaging of Neurotransmitter-Related Molecules2017

    • Author(s)
      Igarashi Hironaka、Ueki Satoshi、Ohno Ken、Ohkubo Masaki、Suzuki Yuji
    • Journal Title

      Journal of Nippon Medical School

      Volume: 84 Issue: 4 Pages: 160-164

    • DOI

      10.1272/jnms.84.160

    • NAID

      130006140098

    • ISSN
      1345-4676, 1347-3409
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow2017

    • Author(s)
      Nakada Tsutomu、Kwee Ingrid、Igarashi Hironaka、Suzuki Yuji
    • Journal Title

      Int J Mol Sci.

      Volume: 18 Issue: 8 Pages: 1798-1798

    • DOI

      10.3390/ijms18081798

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MRI characteristics of the glia limitans externa: A 7T study.2017

    • Author(s)
      Suzuki K, Yamada K, Nakada K, Suzuki Y, Watanabe M, Kwee IL, Nakada T
    • Journal Title

      Magn Reson Imaging

      Volume: 44 Pages: 140-145

    • DOI

      10.1016/j.mri.2017.08.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Slow accumulations of neural activities in multiple cortical regions precede self-initiation of movement: an event-related fMRI study2017

    • Author(s)
      Sakata H, Itoh K, Suzuki Y, Nakamura K, Watanabe M, Igarashi H, Nakada T
    • Journal Title

      eNEURO

      Volume: Oct 30;4(5)

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: A 1H-MR spectroscopy study2017

    • Author(s)
      Shimizu M, Suzuki Y, Yamada K, Ueki S, Watanabe M, Igarashi H, Nakada T
    • Journal Title

      Pediatr Res

      Volume: 27 Issue: 1 Pages: 29-32

    • DOI

      10.1111/jon.12380

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Relationship between reduction of water influx into CSF and senile plaque formation (β-amyloid)2017

    • Author(s)
      Yuji Suzuki
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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