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The glioma convalescence marker development which targeted an RNA-binding factor.

Research Project

Project/Area Number 16K15649
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionKanazawa Medical University

Principal Investigator

NAKAMURA Yuka  金沢医科大学, 総合医学研究所, 助手 (00565632)

Co-Investigator(Renkei-kenkyūsha) ISHIGAKI Yasuhito  金沢医科大学, 総合医学研究所, 教授 (20232275)
AKAI Takuya  富山大学, 附属病院, 講師 (50222500)
NAKADA Mitsutoshi  金沢大学, 医学系, 教授 (20334774)
NAKADA Satoko  金沢医科大学, 医学部, 助教 (30569091)
SHIMASAKI Takeo  金沢医科大学, 総合医学研究所, 准教授 (50377420)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腫瘍マーカー / RNA / 神経膠芽腫 / 神経膠腫 / RNA結合因子
Outline of Final Research Achievements

In order to clarify the significance of high expression of EJC-related factors in glioblastoma (GBM), immunostaining was performed to examine whether there is a difference in survival rate between the group with high expression level and the group with low expression level. As a result, in the high expression group, it was revealed that the overall survival time was significantly shorter than that of the low expression group. In addition, using the Tet-ON system, drug-induced overexpression system was created in GBM cells and genes affected were searched. As a result, we were able to detect a large number of gene fluctuations. We searched the functions of these genes by database and others, and the genes related to GBM occupied. This result seems to suggest that the EJC related factor is the expression regulator of the gene group related to GBM.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2017 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) Remarks (2 results)

  • [Journal Article] High FDG uptake on PET is associated with negative cell-to-cell adhesion molecule E-cadherin expression in lung adenocarcinoma.2017

    • Author(s)
      Higashi K, Ueda Y, Shimasaki M, Ishigaki Y, Nakamura Y, Oguchi M, Takegami T, Watanabe N.
    • Journal Title

      Ann Nucl Med.

      Volume: 31(8) Issue: 8 Pages: 590-595

    • DOI

      10.1007/s12149-017-1187-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] クロマチンモデュレーター蛋白CTCFとHMGA1は血管平滑筋細胞分化をつかさどるmiRNAの遺伝子発現を核骨格上で逆方向に制御する2017

    • Author(s)
      岩井邦充, 五十嵐裕太, 渡邊啓介, 奥野太寿生, 姫野太郎, 大黒正志, 森本茂人,中村有香, 石垣靖人
    • Organizer
      第30回日本老年学会総会・第59回日本老年医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 内皮細胞の核小体蛋白NucleosteminはPro-inflammatory形質への転換促進と抗酸化ストレス酵素の発現を促進する相反作用を内蔵した形で動脈硬化に関与する2017

    • Author(s)
      五十嵐裕太, 岩井邦充, 森田卓朗, 矢野 浩, 入谷 敦, 大黒正志, 森本茂人, 中村有香, 石垣靖人
    • Organizer
      第30回日本老年学会総会・第59回日本老年医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Remarks] http://www.kanazawa-med.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 金沢医科大学 総合医学研究所 遺伝子機能研究分野

    • URL

      http://mri-cellular-biology.kanazawa-med.labos.ac/one/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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