The glioma convalescence marker development which targeted an RNA-binding factor.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15649
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kanazawa Medical University
• Principal Investigator: NAKAMURA Yuka 金沢医科大学, 総合医学研究所, 助手 (00565632)
• Co-Investigator(Renkei-kenkyūsha): ISHIGAKI Yasuhito 金沢医科大学, 総合医学研究所, 教授 (20232275) ; AKAI Takuya 富山大学, 附属病院, 講師 (50222500) ; NAKADA Mitsutoshi 金沢大学, 医学系, 教授 (20334774) ; NAKADA Satoko 金沢医科大学, 医学部, 助教 (30569091) ; SHIMASAKI Takeo 金沢医科大学, 総合医学研究所, 准教授 (50377420)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 腫瘍マーカー / RNA / 神経膠芽腫

Outline of Final Research Achievements

In order to clarify the significance of high expression of EJC-related factors in glioblastoma (GBM), immunostaining was performed to examine whether there is a difference in survival rate between the group with high expression level and the group with low expression level. As a result, in the high expression group, it was revealed that the overall survival time was significantly shorter than that of the low expression group. In addition, using the Tet-ON system, drug-induced overexpression system was created in GBM cells and genes affected were searched. As a result, we were able to detect a large number of gene fluctuations. We searched the functions of these genes by database and others, and the genes related to GBM occupied. This result seems to suggest that the EJC related factor is the expression regulator of the gene group related to GBM.

Free Research Field

細胞生物学