| Project/Area Number |
16K15720
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中川 崇 富山大学, 大学院医学薬学研究部(医学), 准教授 (40610374)
谷山 義明 大阪大学, 医学系研究科, 招へい教授 (60372611)
巽 光朗 大阪大学, 医学部附属病院, 講師 (60397700)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 解糖系 / MCT4 / ノックアウト / 頭頸部扁平上皮癌 / knock out / lactate / 癌 / 糖 |
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| Outline of Final Research Achievements |
Malignant tumors exhibit increased dependence on glycolysis, resulting in abundant production of lactic acid, which is transported to the extracellular by MCT4. We sought to access the possibility of MCT4-targeted therapy. To this end, we developed MCT4 knockout mice, which displayed no severe phenotype, suggesting that the MCT4-targeted therapy would be feasible. We are currently making MCT4 knockout cell lines of head and neck squamous cell carcinoma, which will allow us to do a series of experiment to verify the usefulness of MCT4-targeted therapy, such as increment of radiation sensitivity.
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