Analysis of humoral abnormality caused by functional imbalance of follicular helper T cells.
Project/Area Number |
16K15723
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
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Research Institution | Sapporo Medical University |
Principal Investigator |
Himi Tetsuo 札幌医科大学, 医学部, 教授 (90181114)
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Co-Investigator(Kenkyū-buntansha) |
一宮 慎吾 札幌医科大学, 医学部, 教授 (30305221)
高野 賢一 札幌医科大学, 医学部, 准教授 (70404689)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | ヘルパーT細胞 / 脂質メディエーター / IgG4関連疾患 / 抗体産生 / ヘルパーT 細胞 / アレルギー性鼻炎 / 濾胞ヘルパーT細胞 / 免疫バランス / 機能性リンパ球 / 粘膜関連リンパ装置 / 扁桃 / 濾胞ヘルパーT細胞 / IgG4関連疾患 / 液性免疫 |
Outline of Final Research Achievements |
To determine the pathophysiologic features of diseases regarding immunological dysregulation, we examined subsets of follicular helper T (Tfh) cells and regulatory B (Breg) cells in peripheral blood and affected lesion from allergic rhinitis (AR) and IgG4-RD patients. The results showed skewed polarization of Tfh cell subsets in both AR and IgG4-RD cases. Interestingly, the %Breg cells in total B cells were decreased in AR cases and, more extensively, in AR. Moreover, we found significant correlations of fractional exhaled nitric oxide and blood eosinophil levels with the index %Tfh2 cells per %Breg cells. Our findings indicate that relative decrease in Breg cells under the condition of Tfh2 cell skewing is a putative exaggerating factor of AR to bronchial asthma. Patients with IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) showed increased infiltration of Tfh cells highly expressing PD-1 and ICOS in submandibular glands.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] The Behavior and Role of Lipolysis-stimulated Lipoprotein Receptor, a Component of Tricellular Tight Junctions, in Head and Neck Squamous Cell Carcinomas.2016
Author(s)
Takano K, Kakuki T, Obata K, Nomura K, Miyata R, Kondo A, Kurose M, Kakiuchi A, Kaneko Y, Kohno T, Himi T, Kojima T.
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Journal Title
Anticancer Res
Volume: 36
Pages: 5895-5904
Related Report
Peer Reviewed
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[Journal Article] Efficacy of abatacept for IgG4-related disease over 8months.2016
Author(s)
Yamamoto M, Takahashi H, Takano K, Shimizu Y, Sakurai N, Suzuki C, Naishiro Y, Yajima H, Awakawa T, Himi T, Nakase H.
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Journal Title
Ann Rheum Dis
Volume: 75
Issue: 8
Pages: 1576-1578
DOI
Related Report
Peer Reviewed
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[Journal Article] Bob1 limits cellular frequency of T follicular helper cells2016
Author(s)
Yamashita K, Kawata K, Matsumiya H, Kamekura R, Jitsukawa S, Nagaya T, Ogasawara N, Takano K, Kubo T, Kimura S, Shigehara K, Himi T, Ichimiya S.
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Journal Title
European Journal of Immunology
Volume: in press
Issue: 6
Pages: 1361-1370
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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