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Elucidation of inflammation control mechanism with hypothermia initiated by cold shock protein RBM3

Research Project

Project/Area Number 16K15762
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionNagasaki University

Principal Investigator

TASAKI Osamu  長崎大学, 病院(医学系), 教授 (90346221)

Co-Investigator(Kenkyū-buntansha) 田島 吾郎  長崎大学, 病院(医学系), 助教 (00437427)
山野 修平  長崎大学, 病院(医学系), 助教 (60570538)
梅原 敬弘  長崎大学, 医歯薬学総合研究科(医学系), 助教 (60617421)
池松 和哉  長崎大学, 医歯薬学総合研究科(医学系), 教授 (80332857)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords自然免疫受容体 / 低温ショック蛋白 / 自然免疫系 / 感染症 / 熱傷 / 免疫学
Outline of Final Research Achievements

In this study, we mainly investigated ① involvement of innate immune system in invasive model, ② relationship between RBM3 expression by hypothermia and innate immune receptor expression. As an invasion model of ①, a mouse cecal ligation and puncture model (CLP) and a III degree burn model (Burn) with a body surface area of 20% were prepared. In the infectious invasion model (CLP) and the non-infectious invasion model (Burn), it was revealed that mRNAs of innate immune receptors and downstream signaling molecules show a characteristic reaction pattern. In ②, we also showed that gene expression of cold shock proteins(RBM3, CIRP) and innate immune receptors were significantly increased in an acute phase(3 hours later) of hypothermia model.

Academic Significance and Societal Importance of the Research Achievements

本研究では、感染性モデルと非感染性モデルにおける自然免疫受容体の遺伝子発現が特徴的なパターンを示すことを明らかにした。救急・集中治療領域における重症患者においては熱発を示すことが多いが、本結果は、遺伝子の発現パターンを解析することにより感染性か非感染性の発熱かを鑑別することができる可能性を示している。
低温ショック蛋白(CSP)については、低体温モデルの急性期にCSPの遺伝子発現が有意に上昇すること、自然免疫受容体および下流のシグナル分子群のmRNAの中に上昇するものがあること、および臓器により発現の程度が異なることを明らかにした。今後、蛋白の発現を解明することによりCSPの役割が明らかとなる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2020 2019 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (14 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Early diagnosis using canonical discriminant analysis of innate immune receptor gene expression profiles in a murine infectious or sterile systemic inflammation model2018

    • Author(s)
      Tajima Goro、Tokunaga Ayako、Umehara Takahiro、Ikematsu Kazuya、Miyamoto Junya、Sato Shuntaro、Tasaki Osamu
    • Journal Title

      Journal of Trauma and Acute Care Surgery

      Volume: 84 Issue: 4 Pages: 583-589

    • DOI

      10.1097/ta.0000000000001789

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between Intracranial Pressure or Cerebral Perfusion Pressure and Prognosis in Patients with Severe Traumatic Brain Injury Treated with Mild Hypothermia2017

    • Author(s)
      Hayakawa Koichi、Tasaki Osamu、Iwamura Hiromu、Wada Daiki、Saitou Fukuki、Iba Jiro、Yoshiya Kazuhisa、Ikegawa Hitoshi、Shiozaki Tadahiko、Nakamori Yasushi、Fujimi Satoshi、Shimazu Takeshi、Kuwagata Yasuyuki
    • Journal Title

      Journal of Trauma & Treatment

      Volume: 06 Issue: 02 Pages: 1-6

    • DOI

      10.4172/2167-1222.1000380

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] D-dimerを用いた外傷後静脈血栓塞栓症の新たなスクリーニング基準に関する検討2017

    • Author(s)
      井山 慶大、猪熊 孝実、佐藤 俊太朗、山野 修平、田島 吾郎、平尾 朋仁、田崎 修
    • Journal Title

      日本救急医学会雑誌

      Volume: 28 Pages: 134-144

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 汚染創への対応 四肢開放創へのデブリドマン治療2017

    • Author(s)
      福島 達也、宮本 俊之、田口 憲士、土居 満、岩尾 敦彦、田崎 修
    • Journal Title

      救急医学

      Volume: 41 Pages: 1407-1412

    • Related Report
      2017 Research-status Report
  • [Presentation] THE EXPRESSION OF REPULSIVE GUIDANCE MOLECULE A (RGMA) AFTER TRAUMATIC BRAIN INJURY: THE TIME-COURSE GENE EXPRESSION CHANGES IN THE MURINE CONTROLLED CORTICAL IMPACT MODEL2020

    • Author(s)
      Eri Uemura, Goro Tajima, Naoya Matsumoto, Ayako Tokunaga, Miyuki Miura, Takehiko Murase, Kazuya Ikematsu, Osamu Tasaki.
    • Organizer
      79th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PATTERN-BASED ANALYSIS OF GENE EXPRESSION PROFILE BY CANONICAL DISCRIMINANT ANALYSIS COULD IDENTIFY THE PATHOPHYSIOLOGY REGARDLESS OF THE SEVERITY2020

    • Author(s)
      Goro Tajima, Eri Uemura, Ayako Tokunaga, Miyuki Miura, Takahiro Umehara, Kazuya Ikematsu, Osamu Tasaki.
    • Organizer
      79th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 全身性炎症における自然免疫システムの遺伝子発現パターンによる病態判別2019

    • Author(s)
      田島吾郎、徳永彩子、梅原敬弘、池松和哉、田崎修
    • Organizer
      第47回日本救急医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Novel Method to Discriminate the Pathophysiology of Inflammation by Patterns of Innate Immune System2019

    • Author(s)
      Goro Tajima, Ayako Tokunaga, Takahiro Umehara, Kazuya Ikematsu, Osamu Tasaki
    • Organizer
      Society of Critical Care Medicine 48th Critical Care Congress
    • Related Report
      2018 Research-status Report
  • [Presentation] マウス広範囲熱傷モデルにおける急性期の自然免疫受容体発現変化2018

    • Author(s)
      田島 吾郎、徳永 彩子、梅原 敬弘、池松 和哉、田崎 修
    • Organizer
      第44回日本熱傷学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 組織損傷における全身性炎症の自然免疫受容体発現パターン2018

    • Author(s)
      田島 吾郎、徳永 彩子、梅原 敬弘、池松 和哉、田崎 修
    • Organizer
      第32回日本外傷学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 全身性炎症における自然免疫受容体発現パターンの経時変化2018

    • Author(s)
      田島 吾郎、徳永 彩子、梅原 敬弘、池松 和哉、田崎 修
    • Organizer
      第46回日本救急医学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] EARLY DIAGNOSIS USING CANONICAL DISCRIMINANT ANALYSIS OF INNATE IMMUNE RECEPTOR GENE EXPRESSION PROFILE IN INFECTIOUS OR STERILE SYSTEMIC INFLAMMATION2017

    • Author(s)
      Goro Tajima, Ayako Tokunaga, Takahiro Umehara, Kazuya Ikematsu, Osamu Tasaki
    • Organizer
      76th Annual Meeting of the American Association for the Surgery of Trauma and Clinical Congress of Acute Care Surgery
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 全身性炎症における自然免疫受容体発現パターンによる早期病態判別法2017

    • Author(s)
      田島 吾郎、徳永 彩子、梅原 敬弘、池松 和哉、田﨑 修
    • Organizer
      日本救急医学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 外傷後静脈血栓塞栓症の新規予防法に関する検討2017

    • Author(s)
      井山 慶大, 猪熊 孝実, 池田 聡司, 高橋 健介, 山野 修平, 田島 吾郎, 平尾 朋仁, 野崎 義宏, 山下 和範, 前村 浩二, 田崎 修
    • Organizer
      日本救急医学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] DCO:Damage Control Orthopedics 長崎大学病院におけるDamage Control Orthopaedics(DCO)の実際2017

    • Author(s)
      宮本 俊之, 福島 達也, 田口 憲士, 尾崎 誠, 田崎 修
    • Organizer
      日本外傷学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当センターにおける頸髄損傷患者の気管切開適応に関する検討2017

    • Author(s)
      野崎 義宏, 山下 和範, 猪熊 孝実, 山野 修平, 田島 吾郎, 平尾 朋仁, 高橋 健介, 松本 直也, 村橋 志門, 田崎 修
    • Organizer
      日本外傷学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 全身性炎症における自然免疫受容体発現パターンによる感染症診断法2016

    • Author(s)
      田島吾郎、梅原敬弘、池松和哉、田﨑修
    • Organizer
      日本救急医学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都・港区)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Infection diagnosis in systemic inflammation by innate immune expression pattern2016

    • Author(s)
      Tajima G, Umehara T, Ikematsu K, Tasaki O
    • Organizer
      75th Annual meeting of the American association for the surgery of trauma and clinical congress of acute care surgery
    • Place of Presentation
      Waikiloa(USA)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2021-02-19  

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