| Project/Area Number |
16K15773
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大峡 淳 新潟大学, 医歯学系, 教授 (40266169)
井上 佳世子 (野澤佳世子) 新潟大学, 医歯学総合研究科, 特任准教授 (90303130)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 赤唇 / RNA-seq解析 / 再生 / 歯学 / 発生・分化 |
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| Outline of Final Research Achievements |
Vermillion is a human-specific tissue whose reconstruction is esthetically important. However, due to its unique nature, it is impossible to clarify its specificity using animal models. In order to elucidate the tissue specificity of the vermillion, this project examined which molecules are expressed in the adult vermillion. The vermillion expressed long noncoding RNA (lncRNA) and small nuclear RNA (snRNA) more than in the lip mucosa, in addition to PAX gene with the homeobox. Many genes including PPDPF were detected as molecules which never expressed in the mucosa but strongly only in the vermillion. These data suggest that the specificity of the vermillion is controlled by different molecular mechanism from the mucosa.
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