Investigation for aspiration pneumonia severity control method using rice-derived protease inhibitors
| Project/Area Number |
16K15785
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Niigata University |
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Principal Investigator |
YUTAKA Terao 新潟大学, 医歯学系, 教授 (50397717)
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| Co-Investigator(Kenkyū-buntansha) |
谷口 正之 新潟大学, 自然科学系, 教授 (00163634)
土門 久哲 新潟大学, 医歯学系, 助教 (00594350)
前川 知樹 新潟大学, 医歯学系, 研究准教授 (50625168)
小田 真隆 京都薬科大学, 薬学部, 教授 (00412403)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症制御 / 誤嚥性肺炎 |
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| Outline of Final Research Achievements |
In order to evaluate the anti-inflammatory effect of bacterial infection of rice derived from rice, bacterial LPS was added to mouse macrophage-derived RAW 264.7 cells pretreated with peptide, and the transcriptional activity of inflammatory cytokines was measured by Real-time PCR And analyzed. Transcription activity of related factors was also measured. Next, in order to verify the inflammatory control effect of the peptide, in in vitro system using RAW 264.7 cells, the rice derived from the rice increased the transcription activity of osteoclast differentiation factor by LPS-induced inflammation and RANKL addition Respectively. It was suggested that the rice peptides selected in this study could have a defense effect against the inflammation caused by bacterial infection.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-like Receptors and Cytokines in Pneumococcal Pneumonia.2018
Author(s)
Domon H, Nagai K, Maekawa T, Oda M, Yonezawa D, Takeda W, Hiyoshi T, Tamura H, Yamaguchi M, Kawabata S, Terao Y
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Journal Title
Front Immunol
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Sulfated vizantin induces the formation of macrophage extracellular traps.2018
Author(s)
Oda M, Kurosawa M, Yamamoto H, Domon H, Kimura T, Isono T, Maekawa T, Hayashi N, Yamada N, Furue Y, Kai D, Terao Y
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Journal Title
Microbiol Immunol.
Volume: 印刷中
NAID
Related Report
Peer Reviewed
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[Journal Article] Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4.2018
Author(s)
Nagai K, Domon H., Maekawa T, Oda M, Hiyoshi T, Tamura H, Yonezawa D, Arai Y, Yokoji M, Tabeta K, Habuka R, Saitoh A, Yamaguchi M, Kawabata S, Terao Y
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Journal Title
Cell Immunol
Volume: 325
Pages: 14-22
Related Report
Peer Reviewed
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[Journal Article] Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers.2017
Author(s)
Murakami T, Saitoh I, Sato M, Inada E, Soda M, Oda M, Domon H, Iwase Y, Sawami T, Matsueda K, Terao Y, Ohshima H, Noguchi H, Hayasaki H
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Journal Title
Arch Oral Biol
Volume: 81
Pages: 110-120
Related Report
Peer Reviewed
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