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Development of a method for the endochondral alveolar bone tissue engineering using iPS cells

Research Project

Project/Area Number 16K15797
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionTohoku University

Principal Investigator

Egusa Hiroshi  東北大学, 歯学研究科, 教授 (30379078)

Co-Investigator(Kenkyū-buntansha) 鎌野 優弥  東北大学, 大学病院, 助教 (70757260)
Co-Investigator(Renkei-kenkyūsha) SAITO Masahiro  東北大学, 大学院歯学研究科, 教授 (40215562)
FUKUMOTO Satoshi  東北大学, 大学院歯学研究科, 教授 (30264253)
Research Collaborator OKAWA Hiroko  東北大学, 大学院歯学研究科, 非常勤講師 (00781296)
KOSAKA Yukihiro  東北大学, 大学院歯学研究科, 大学院生
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords再生歯科補綴学 / iPS細胞 / 軟骨内骨化 / 再生歯学
Outline of Final Research Achievements

A strategy of induced pluripotent stem (iPS) cell-based alveolar bone regeneration is expected to improve treatment outcome in prosthetic treatments. We focused on possible advantage in endochondral bone regeneration in the large bone defect. The aim of this study was to develop a method to fabricate bone/cartilage-like cell constructs using iPS cells. We found that combination use of chondrogenic and osteogenic induction factors could guide mouse iPS cell embryoid bodies into hybrid bone/cartilage-like cell constructs on the manipulation of a ratio in degrees of chondrocyte/osteoblast differentiation.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 8 results)

  • [Journal Article] Current bone substitutes for implant dentistry2018

    • Author(s)
      Yamada M, Egusa H
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 62 Issue: 2 Pages: 152-161

    • DOI

      10.1016/j.jpor.2017.08.010

    • NAID

      130006733089

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Challenges for stem cell-based “regenerative prosthodontics”2017

    • Author(s)
      Niibe K, Suehiro F, Oshima M, Nishimura M, Kuboki T, Egusa H
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 61 Issue: 1 Pages: 3-5

    • DOI

      10.1016/j.jpor.2016.09.001

    • NAID

      130005465202

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] iPS cell-based strategies in bone tissue engineering2017

    • Author(s)
      Egusa H
    • Organizer
      The 2nd Annual Academic Conference of Society of Dental Research Administration, CSA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS細胞を用いた骨再生医療戦略2017

    • Author(s)
      江草 宏
    • Organizer
      東北大学金属材料研究所共同研究ワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Emerging approaches for “regenerative prosthodontics”2017

    • Author(s)
      Egusa H
    • Organizer
      2017 Biennial Joint Congress of JPS-CPS-KAP
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS cell-based strategies in bone tissue engineering2017

    • Author(s)
      Egusa H
    • Organizer
      第65回 国際歯科研究学会 日本部会(JADR)学術大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] インプラント臨床における再生医療の現状と挑戦2017

    • Author(s)
      江草 宏
    • Organizer
      第37回 日本口腔インプラント学会 近畿・北陸支部学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 再生歯科医療を材料と生体から理解する2016

    • Author(s)
      江草 宏
    • Organizer
      大阪口腔インプラント研究会例会 シンポジウム「組織再生の最前線」
    • Place of Presentation
      大阪市
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] iPS細胞が描く歯科医療の未来 ~これからの再生歯科医療への期待と課題~2016

    • Author(s)
      江草 宏
    • Organizer
      第69回東北地区歯科医学会
    • Place of Presentation
      仙台市
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] iPS細胞を用いた骨組織再生技術の開発2016

    • Author(s)
      江草 宏
    • Organizer
      第59回春季日本歯周病学会学術大会 シンポジウム「大規模歯周組織再生を目指した細胞治療開発の新展開」
    • Place of Presentation
      鹿児島市
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2019-12-27  

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