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Elucidation of soft tissue adhesion mechanism to zirconia and titanium surfaces

Research Project

Project/Area Number 16K15798
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Hanawa Takao  東京医科歯科大学, 生体材料工学研究所, 教授 (90142736)

Co-Investigator(Kenkyū-buntansha) 堤 祐介  東京医科歯科大学, 生体材料工学研究所, 准教授 (60447498)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsイットリア安定化ジルコニア / チタン / ハンクス液 / 表面反応 / 表面分析 / 軟組織接着 / 歯科インプラント / 擬似体液 / ジルコニア / 軟組織 / 細胞 / 接着
Outline of Final Research Achievements

Change in surface chemical state of yttria-stabilized zirconia (Y-TZP) before and after immersion in water and Hanks' solution was characterized using XPS. Y-TZP reacted with water molecules and surface hydroxyl groups increased. In Hanks' solution, Y-TZP reacted with phosphate ions as well as water molecules and phosphate was formed in the addtion of the increase of hydroxyl groups, while caocium ion was not incorporated and calcium phosphate was not formed on itself.

Academic Significance and Societal Importance of the Research Achievements

イットリア安定化ジルコニア(Y-TZP)は人工股関節や歯科材料として臨床応用されている。Y-TZPは硬組織と化学的に直接結合しない一方で、軟組織とは直接結合するが、その結合メカニズムは解明されていない。これまでにY-TZPへCO2レーザー照射し、表面濡れ性向上によるY-TZPの接着性を改善する研究などが行われてきたが、Y-TZP自体に対する解析は行われていなかった。本研究によって、Y-TZPが軟組織と接着するが硬組織とは結合しないメカニズムを明らかにすることができた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017 2016 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Journal Article] Surface characterization of commercially available yttria-stabilized tetragonal zirconia polycrystalline in water and Hanks’ solution using X-ray photoelectron spectroscopy2019

    • Author(s)
      Oishi M, Tsutsumi Y, Chen P, Nakaishi M, Shida M, Doi H, Hanawa T
    • Journal Title

      Dental Materials Journal

      Volume: 38 Issue: 3 Pages: 496-504

    • DOI

      10.4012/dmj.2018-299

    • NAID

      130007657717

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2019-05-29
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surface changes of yttria‐stabilized zirconia in water and Hanks solution characterized using XPS2018

    • Author(s)
      M. Oishi, Y. Tsutsumi, P. Chen, M. Ashida, H. Doi, T. Hanawa
    • Journal Title

      Surface nad Interface Analysis

      Volume: 50 Issue: 5 Pages: 578-591

    • DOI

      10.1002/sia.6435

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] イットリア安定化ジルコニア表面の水中およびハンクス液中での変化2017

    • Author(s)
      大石誠、堤裕介、陳鵬、蘆田茉希、土居寿、塙隆夫
    • Organizer
      日本金属学会2017年春期(第159回)大会
    • Place of Presentation
      首都大学東京(八王子市・東京都)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Reaction of yttria-stabilized zirconia surface with water and Hanks’ solution2017

    • Author(s)
      Oishi M, Hanawa T, Tsutsumi Y, Chen P, Doi H
    • Organizer
      26th Annual Conference of the European Society for Biomaterials (ESB2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Chenge in surafce of yttria-stabilized zirconia in water nad Hanks' solution characterized using XPS2016

    • Author(s)
      Oishi M, Tsutsumi Y, Chen P, Doi H, Hanawa T
    • Organizer
      International Dental Materials COngress 2016
    • Place of Presentation
      Legian, Bali (Indonesia)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] 生体材料工学研究所金属生体材料学分野

    • URL

      http://www.tmd.ac.jp/i-mde/www/metal/metal-j.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 東京医科歯科大学生体材料工学研究所金属生体材料学分野

    • URL

      http://www.tmd.ac.jp/i-mde/www/metal/metal-j.html

    • Related Report
      2017 Research-status Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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