Elucidation of soft tissue adhesion mechanism to zirconia and titanium surfaces

• Project/Area Number: 16K15798
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Hanawa Takao 東京医科歯科大学, 生体材料工学研究所, 教授 (90142736)
• Co-Investigator(Kenkyū-buntansha): 堤 祐介 東京医科歯科大学, 生体材料工学研究所, 准教授 (60447498)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: イットリア安定化ジルコニア / チタン / ハンクス液 / 表面反応 / 表面分析 / 軟組織接着 / 歯科インプラント / 擬似体液 / ジルコニア / 軟組織 / 細胞 / 接着

Outline of Final Research Achievements

Change in surface chemical state of yttria-stabilized zirconia (Y-TZP) before and after immersion in water and Hanks' solution was characterized using XPS. Y-TZP reacted with water molecules and surface hydroxyl groups increased. In Hanks' solution, Y-TZP reacted with phosphate ions as well as water molecules and phosphate was formed in the addtion of the increase of hydroxyl groups, while caocium ion was not incorporated and calcium phosphate was not formed on itself.

Academic Significance and Societal Importance of the Research Achievements

イットリア安定化ジルコニア（Y-TZP）は人工股関節や歯科材料として臨床応用されている。Y-TZPは硬組織と化学的に直接結合しない一方で、軟組織とは直接結合するが、その結合メカニズムは解明されていない。これまでにY-TZPへCO2レーザー照射し、表面濡れ性向上によるY-TZPの接着性を改善する研究などが行われてきたが、Y-TZP自体に対する解析は行われていなかった。本研究によって、Y-TZPが軟組織と接着するが硬組織とは結合しないメカニズムを明らかにすることができた。

Research Products

• [Journal Article] Surface characterization of commercially available yttria-stabilized tetragonal zirconia polycrystalline in water and Hanks’ solution using X-ray photoelectron spectroscopy (2019)
  • Author(s): Oishi M, Tsutsumi Y, Chen P, Nakaishi M, Shida M, Doi H, Hanawa T
  • Journal Title: Dental Materials Journal Volume: 38 Issue: 3 Pages: 496-504
  • DOI: 10.4012/dmj.2018-299
  • NAID: 130007657717
  • ISSN: 0287-4547, 1881-1361
  • Year and Date: 2019-05-29
  • Peer Reviewed
• [Journal Article] Surface changes of yttria‐stabilized zirconia in water and Hanks solution characterized using XPS (2018)
  • Author(s): M. Oishi, Y. Tsutsumi, P. Chen, M. Ashida, H. Doi, T. Hanawa
  • Journal Title: Surface nad Interface Analysis Volume: 50 Issue: 5 Pages: 578-591
  • DOI: 10.1002/sia.6435
  • Peer Reviewed
• [Presentation] イットリア安定化ジルコニア表面の水中およびハンクス液中での変化 (2017)
  • Author(s): 大石誠、堤裕介、陳鵬、蘆田茉希、土居寿、塙隆夫
  • Organizer: 日本金属学会2017年春期（第159回）大会
  • Place of Presentation: 首都大学東京（八王子市・東京都）
  • Year and Date: 2017-03-17
• [Presentation] Reaction of yttria-stabilized zirconia surface with water and Hanks’ solution (2017)
  • Author(s): Oishi M, Hanawa T, Tsutsumi Y, Chen P, Doi H
  • Organizer: 26th Annual Conference of the European Society for Biomaterials (ESB2017)
  • Int'l Joint Research
• [Presentation] Chenge in surafce of yｔtria-stabilized zirconia in water nad Hanks' solution characterized using XPS (2016)
  • Author(s): Oishi M, Tsutsumi Y, Chen P, Doi H, Hanawa T
  • Organizer: International Dental Materials COngress 2016
  • Place of Presentation: Legian, Bali (Indonesia)
  • Year and Date: 2016-11-05
  • Int'l Joint Research
• [Remarks] 生体材料工学研究所金属生体材料学分野
  • URL: http://www.tmd.ac.jp/i-mde/www/metal/metal-j.html
• [Remarks] 東京医科歯科大学生体材料工学研究所金属生体材料学分野
  • URL: http://www.tmd.ac.jp/i-mde/www/metal/metal-j.html