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Development of novel diagnostic technology for marfan syndrome using periodontal tissue

Research Project

Project/Area Number 16K15844
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Periodontology
Research InstitutionTohoku University

Principal Investigator

Saito Masahiro  東北大学, 歯学研究科, 教授 (40215562)

Co-Investigator(Kenkyū-buntansha) 吉田 恭子 (今中恭子)  三重大学, 医学系研究科, 准教授 (00242967)
石河 真幸  東北大学, 大学病院, 助教 (60432936)
Co-Investigator(Renkei-kenkyūsha) 石河 真幸  東北大学, 歯学研究科, 助教 (60432936)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords結合組織疾患 / マルファン症候群 / 組織破壊 / 細胞外マトリックス / イメージング診断 / 解離性大動脈瘤 / 歯周炎 / モノクローナル抗体 / 弾性システム / 歯学 / トランスレーショナルリサーチ / 循環器 / バイオテクノロジー / 医療
Outline of Final Research Achievements

Marfan syndrome is a genetic connective tissue disease that caused by mutation of fibrillin-1 that is a major component of microfibril. Main cause of death of marfan syndrome is aortic aneurysm and dissection, however no reliable diagnostic method is available at present. In this project, we tried to develop a novel diagnostic technology of aortic aneurysm and dissection that investigating microfibril structure using anti-fibrillin-1 antibody. We generated immunostaining technology that is able to stain microfibril in the human aorta using anti-fibrillin-1 antibody. The diagnostic technology that suspect aortic aneurysm and dissection is going to develop by using gigival tissue obtained from marfan syndrome patient.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Journal Article] Fibrillin-1 insufficiency alters periodontal wound healing failure in a mouse model of Marfan syndrome.2018

    • Author(s)
      Handa K, Abe S, Suresh VV, Fujieda Y, Ishikawa M, Orimoto A, Kobayashi Y, Yamada S, Yamaba S, Murakami S, Saito M.
    • Journal Title

      Arch Oral Biol.

      Volume: 90 Pages: 53-60

    • DOI

      10.1016/j.archoralbio.2018.02.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metal ions from S‐PRG filler have the potential to prevent periodontal disease2017

    • Author(s)
      Yoko Iwamatsu‐Kobayashi, Syouta Abe, Yoshiyasu Fujieda, Ai Orimoto, Masafumi Kanehira, Keisuke Handa, Venkata Suresh Venkataiah, Wei Zou, Masaki Ishikawa, Masahiro Saito
    • Journal Title

      Clinical and Experiment Dental Research

      Volume: 3 Issue: 4 Pages: 126-133

    • DOI

      10.1002/cre2.70

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] F-spondin negatively regulates dental follicle differentiation through the inhibition of TGF-beta activity.2017

    • Author(s)
      Orimoto A, Kurokawa M, Handa K, Ishikawa M, Nishida E, Aino M, Mitani A, Ogawa M, Tsuji T Saito M
    • Journal Title

      Arch Oral Biol

      Volume: 79 Pages: 7-13

    • DOI

      10.1016/j.archoralbio.2017.02.019

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 歯周組織再生医療の開発と課題2017

    • Author(s)
      齋藤正寛
    • Organizer
      第16回日本再生医療学会総
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 腔と全身の疾患を繋げる共通の標的:メカノバイオロジーを介した結合組織疾患発症機構の解析2017

    • Author(s)
      齋藤正寛
    • Organizer
      第147回日本歯科保存学会秋季学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Role of ADAMTSL6 on aortic aneurysm and dissection in Marfan syndrome2017

    • Author(s)
      Masahiro Saito
    • Organizer
      Gordon reserch conference Elastin, Elastic fibers & microfibrils
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脂肪由来幹細胞を用いた歯周組織再生療法の開発:ブタモデルを用いた他家移植モデルの確立2017

    • Author(s)
      V ベンカタ スレッシュ、半田 慶介、竹立 匡秀、村上 伸也、齋藤 正寛
    • Organizer
      第146回保存学会日本歯科保存学会春季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ADAMTSL6βを介したMarfan症候群の解離性大動脈瘤発症機構の解析2017

    • Author(s)
      折本 愛、二木 正晴、石河 真幸、半田 慶介、齋藤 正寛
    • Organizer
      第146回保存学会日本歯科保存学会春季学術大会2017年6月9日
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pannexin 3は新骨形成制御因子である2017

    • Author(s)
      石河真幸、 Geneva L. Williams、折本愛 、半田慶介 、山田吉彦 、齋藤正寛
    • Organizer
      結合組織学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ADAMTS superfamilyによるMarfan症候群の解離性大動脈瘤発症機構の解析2017

    • Author(s)
      折本愛、石河 真幸、半田慶介、千々岩みゆき、望月早月、村澤祐介、磯貝善 蔵、岡田保典、齋藤正寛
    • Organizer
      結合組織学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ADAMTSL6beta exacerbates tissue destruction of aortic aneurysm and dissection in Marfan syndrome mouse model through promotion of ADAMTS4 activity.2016

    • Author(s)
      Orimoto A, Murasawa Y, Isogai Z, Chijiiwa M, Mochizuki S, Imanaka- Yoshida K, Okada Y and Saito M
    • Organizer
      ASMB2016
    • Place of Presentation
      St. Petersburg, Florida, USA
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 未分化骨芽細胞細胞移植による歯槽骨再生療法について(第一報)ブタ歯槽骨由来未分化骨芽細胞の特性2016

    • Author(s)
      半田慶介、丸山顕太郎、根本英二、齋藤正寛
    • Organizer
      第59回秋季日本歯周病学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Immature osteoblast derived from micro-mini pig for periodontal tissue regeneration.2016

    • Author(s)
      V. Venkata Suresh, Keisuke Handa, Masahiro Saito.
    • Organizer
      IADR
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2016-06-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ADAMTSL6β accelerated ADAMTS4 activity to enhance DAA in MFS.2016

    • Author(s)
      Ai Orimoto, Masaharu Futagi, Masaki Ishikawa, Keisuke Handa, Masahiro Saito
    • Organizer
      IADR
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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