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Development of oral care application using rice-derived peptide material and peptide medicine for periodontal disease

Research Project

Project/Area Number 16K15845
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Periodontology
Research InstitutionNiigata University

Principal Investigator

TABETA Koichi  新潟大学, 医歯学系, 教授 (20401763)

Co-Investigator(Kenkyū-buntansha) 谷口 正之  新潟大学, 自然科学系, 教授 (00163634)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords歯周炎 / ペプチド / 抗炎症 / 抗炎症作用 / コメ / 歯周炎モデルマウス / ペプチド医薬 / 歯学
Outline of Final Research Achievements

The aim of this study was to clarify the suppressive ability of AmyΙ-1-18 peptide and action mechanism against periodontal disease. AmyΙ-1-18 peptide inhibited alveolar bone resorption in mouse periodontitis model via suppressing inflammatory cytokine production. Furthermore, AmyΙ-1-18 peptide suppressed inflammatory cytokine induced by LPS and IL-1β in macrophage. It was shown that AmyΙ-1-18 peptide has anti-inflammatory property and suppresses periodontal disease. The results of this study using mice demonstrated the potency of AmyΙ-1-18 as a novel peptide agent for application in periodontal therapy.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により,コメ由来AmyΙ-1-18ペプチドが抗炎症作用を有すること,歯周病を抑制することが明らかとなり,歯周病に対抗する新規の治療薬開発につながる可能性を示すことができた.未だ40歳で80%の罹患率とされる歯周病の予防及び治療へと発展することで,国民のQOL向上に大きく貢献し得ると考えている.また,AmyΙ-1-18ペプチドがもつLPS中和能や抗炎症作用により,菌血症やリウマチ,クローン病などの炎症性疾患の治療への応用も期待される.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2019 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] The AmyI‐1‐18 peptide derived from rice inhibits alveolar bone resorption via suppression of inflammatory cytokine production induced by lipopolysaccharide and interleukin‐1β in mice2019

    • Author(s)
      Aoki‐Nonaka Yukari、Tabeta Koichi、Yokoji Mai、Matsugishi Aoi、Matsuda Yumi、Takahashi Naoki、Sulijaya Benso、Domon Hisanori、Terao Yutaka、Taniguchi Masayuki、Yamazaki Kazuhisa
    • Journal Title

      Journal of Periodontology

      Volume: . Issue: 10 Pages: 1160-1169

    • DOI

      10.1002/jper.18-0630

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 米由来抗菌ペプチドの歯周炎モデルマウスにおける抗炎症作用の検討2017

    • Author(s)
      野中由香莉、多部田康一、横地麻衣、松田由実、山崎和久、吉江弘正
    • Organizer
      第60回春季日本歯周病学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] コメ由来抗菌ペプチドの抗炎症作用と創傷治癒作用の解析2016

    • Author(s)
      野中由香莉,横地麻衣,多部田康一,山崎和久
    • Organizer
      第59回秋季日本歯周病学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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