Occurrence of pharmaceuticals in wastewater from medical institutions and development of advanced water treatment systems
| Project/Area Number |
16K16218
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental risk control and evaluation
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
Takashi Azuma 大阪薬科大学, 薬学部, 助教 (10634222)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 医薬品類 / 病院排水 / 下水処理場 / 河川環境 / 除去効率 / 負荷量 / 高度処理 / 生物処理 / 環境リスク緩和措置 / 河川 / 汚濁負荷 / 環境技術 / オゾン処理 / 流域管理 |
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| Outline of Final Research Achievements |
Occurrence of pharmaceuticals in hospital effluents in Japan was investigated. The results indicate that multiple compounds were detectable in hospital effluents over a wide concentration range. Although these detected compounds were partly removed in the conventional water treatment processes done in the sewage treatment plants, the remaining amounts were discharged to the river environment, and higher contribution to the mass flux of pharmaceuticals in hospital effluents to river waters was observed in some compounds. Ozonation was effective in removing large amounts of these recalcitrant compounds, indicating the effectiveness of installing advanced water treatment systems not only in sewage treatment plants but also in hospitals before discharge of the wastewater.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、医療機関に由来する排水中に存在する医薬品の存在実態と環境への負荷影響を明らかにするとともに、環境中に流入する医薬品成分による環境リスクの削減又は軽減対策として、水処理の高度化の展望を明らかにしている。本研究により得られた成果は、医療先進国であることが知られている日本において意義深く、欧米等の先進国や、急速に発展を続けるアジア諸国においても同様の対策検討の発展への寄与が期待される。
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Environmental fate of pharmaceutical compounds and antimicrobial-resistant bacteria in hospital effluents, and contributions to pollutant loads in the surface waters in Japan2019
Author(s)
Azuma T., Otomo K., Kunitou M., Shimizu M., Hosomaru K., Mikata S., Ishida M., Hisamatsu K., Yunoki A., Mino Y., Hayashi T.
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Journal Title
Science of the Total Environment
Volume: 657
Pages: 476-484
DOI
Related Report
Peer Reviewed
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[Journal Article] 医療機関に由来する排水中に存在する医薬品成分と高度処理技術の開発2018
Author(s)
東 剛志, 石打浩隆, 井ノ山智美, 寺西裕亮, 山岡美里, 有馬夏美, 塚田 愛, 平見 悟, 松岡里枝, 森分亮伍, 石田真麻, 久松佳苗, 柚木彩実, 大友香奈, 國頭茉莉, 清水麻衣, 細丸 薫, 三方志織, 三野芳紀, 天滿 敬, 林 哲也
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Journal Title
CIRCULATION CONTROL
Volume: 39
Issue: 1
Pages: 24-27
DOI
NAID
ISSN
0389-1844
Related Report
Peer Reviewed / Open Access
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[Journal Article] Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river2017
Author(s)
Azuma T., Arima N., Tsukada A., Hirami S., Matsuoka R., Moriwake R., Ishiuchi H., Inoyama T., Teranishi Y., Yamaoka M., Ishida M., Hisamatsu K., Yunoki A., Mino Y.
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Journal Title
Environmental Science and Pollution Research
Volume: 24
Issue: 23
Pages: 1901-19030
DOI
Related Report
Peer Reviewed
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[Presentation] Distribution of pharmaceuticals in clinical wastewater from medical institutions and development of advanced water treatment systems2017
Author(s)
Azuma T., Otomo K., Kunitou M., Shimizu M., Hosomaru K., Mikata S., Ishida M., Hisamatsu K., Yunoki A., Hisamatsu K., Yunoki A., Arima N., Tsukada A., Hirami S., Matsuoka R., Moriwake R., Ishiuchi H., Inoyama T., Teranishi Y., Yamaoka M., Mino Y., Tenma T., Fujimoto Y. Hayashi T.
Organizer
15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology 2017 (IATDMCT 2017)
Related Report
Int'l Joint Research / Invited
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[Presentation] Distribution of pharmaceutically active compounds in clinical wastewater from hospital effluent in Japan2016
Author(s)
Azuma T., Arima N., Tsukada A., Hirami S., Matsuoka R., Moriwake R., Ishiuchi H., Inoyama T., Teranishi Y., Yamaoka M., Mino Y., Hayashi T., Fujita Y., Masada M.
Organizer
IWA World Water Congress & Exhibition 2016
Place of Presentation
Brisbane, Australia
Year and Date
2016-10-09
Related Report
Int'l Joint Research
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[Presentation] 医療機関に由来する排水を対象にした水処理技術の開発2016
Author(s)
東 剛志, 大友香奈, 國頭茉莉, 清水麻衣, 細丸 薫, 三方志織, 石田真麻, 久松佳苗, 柚木彩実, 三野芳紀, 林 哲也, 藤田芳一, 政田 幹夫
Organizer
第66回日本薬学会近畿支部総会・大会
Place of Presentation
大阪薬科大学（大阪府高槻市）
Related Report
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