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Clinical application of diagnostic technology for blood flow related diseases by using in-vivo blood flow velocimetry method

Research Project

Project/Area Number 16K16412
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical systems
Research InstitutionNational Institute of Technology, Toyama College

Principal Investigator

Akiguchi Shunsuke  富山高等専門学校, その他部局等, 准教授 (50462130)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords血流速度 / in-vivo計測 / イメージング / LDV / 血管血流分布画像 / レーザードップラー流速分布測定装置 / 診断技術 / 面計測 / 皮膚内部血管イメージング
Outline of Final Research Achievements

The purpose of this subject is to develop a laser Doppler velocimetry device capable of completely non-invasive in vivo measurement, and to apply it to the observation of blood flow related diseases. We set as targets that high-speed processing for real-time imaging and vascular distribution judgment in peripheral blood vessels. For the first target, we confirmed that it was possible to complete the process within the target time. The target time is the time it takes to acquire the number of data required to perform the FFT. For the second target, we confirmed that it could not be achieved by the previous method using the Doppler frequency. Therefore, we solved the problem by developing a method that also focused on the scattered light.

Academic Significance and Societal Importance of the Research Achievements

血流状況を非侵襲でリアルタイムに精度良く観察することは従来困難であったが、本課題の技術を応用することで患者の負担を軽減しながら達成できる可能性がある。また、当初予定していたものに加え、例えば末梢部血管での異常が検出されることがある糖尿病患者に対する診断装置としての利用といった応用も可能となり、本装置の適用範囲が広がった。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Three-dimensional imaging of absolute blood flow velocity and blood vessel position under low blood flow velocity based on Doppler signal information included in scattered light from red blood cells2017

    • Author(s)
      T. Kyoden,S. Akiguchi,T.Tajiri,T. Andoh,T. Hachiga
    • Journal Title

      Journal of Applied Physics

      Volume: 122 Issue: 19

    • DOI

      10.1063/1.4994080

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo visualization method by absolute blood flow velocity based on speckle and fringe pattern using two-beam multipoint laser Doppler velocimetry2016

    • Author(s)
      T.Kyoden, N.Shoji, S.Akiguchi, H.Ishida, Y.Takada, N.Momose, T.Homae and T.Hachiga
    • Journal Title

      Journal of Allied Physics

      Volume: 120 Issue: 8

    • DOI

      10.1063/1.4961611

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Examining the Relationship between Blood Flow Velocity and Movement of Erythrocytes in a Capillary using Laser Doppler Velocimetry2016

    • Author(s)
      S. Akiguchi, H. Ishida, Y. Takada, T. Teranishi, T. Andoh and T. Hachiga
    • Journal Title

      IEEJ Transactions on Electrical and Electronic Engineering

      Volume: 11 Issue: 4 Pages: 451-456

    • DOI

      10.1002/tee.22262

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Visualization Method of Blood Flowing by Laser Doppler Velocimetry Using Speckle and Fringe Pattern2017

    • Author(s)
      Shunsuke Akiguchi, Tomoaki Kyoden, Shoji Naruki, Tomoki Tajiri, Tsugunobu Andoh, Hiroki Ishida, Tadashi Hachiga
    • Organizer
      The 6th International Symposium on Organic and Inorganic Electronic Materials and Related Nanotechnologies (EM-NANO2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] REAL-TIME VISUALIZATION SYSTEM OF BLOOD FLOW VELOCITY DISTRIBUTION USING CROSS-SECTIONAL MULTIPOINT LDV2017

    • Author(s)
      N. SHOJI, S. AKIGUCHI, T. KYODEN, T. ANDOH, T. HACHIGA and H. KIKURA
    • Organizer
      The 11th Pacific Symposium on Flow Visualization and Image Processing
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] STUDY ON MULTIPOINT TEMPERATURE MEASUREMENT USING LASER INTERFEROMETRY2016

    • Author(s)
      Naruki Shoji, Tomoaki Kyoden, Shunsuke Akiguchi, Tomotaka Homae, Noboru Momose, Hideaki Yoshioka, and Tadashi Hachiga
    • Organizer
      Proceedings of the 4th International Forum on Heat Transfer 2016
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 多点同時LDVによるin-vivo血流イメージングに影響を及ぼす皮膚の存在とその有効性2016

    • Author(s)
      荘司成熙, 秋口俊輔, 経田僚昭, 百生 登, 八賀正司
    • Organizer
      第55回 日本生体医工学会大会
    • Place of Presentation
      富山国際会議場、 富山市民プラザ(富山県富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 近赤外レーザードップラー流速分布計測装置の皮膚癌診断と治療への応用2016

    • Author(s)
      秋口俊輔, 荘司成煕, 経田僚昭, 百生登, 保前友高, 八賀正司
    • Organizer
      第55回 日本生体医工学会大会
    • Place of Presentation
      富山国際会議場、 富山市民プラザ(富山県富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Measurement of Relationship Between Blood Flow Velocity and Movement of Erythrocytes2016

    • Author(s)
      Shunsuke Akiguchi, Tomoaki Kyoden and Tadashi Hachiga
    • Organizer
      International Conference on Engineering and Technology 2016
    • Place of Presentation
      富山県民会館(富山県富山市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study on Multipoint Temperature Measurement Using Laser Interferometry2016

    • Author(s)
      Naruki SHOJI, Shunsuke AKIGUCHI, Tomoaki KYODEN, Tomotaka HOMAE, Noboru MOMOSE, Hideaki YOSHIOKA and Tadashi HACHIGA
    • Organizer
      International Conference on Engineering and Technology 2016
    • Place of Presentation
      富山県民会館(富山県富山市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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