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Improvement and evaluation of blood oxygenation measurement system based on photoacoustic technique

Research Project

Project/Area Number 16K16413
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical systems
Research InstitutionNational Defense Medical College

Principal Investigator

Takeshi Hirasawa  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 医用工学, 助教 (60583086)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords光音響イメージング / 血液酸素飽和度計測 / 分光イメージング / 非侵襲計測 / 血液酸素飽和度 / 光超音波 / マルチスペクトル / 分光計測 / 光音響 / 周波数解析 / 光音響画像 / 機能イメージング / 光学特性 / ウェーブレット変換
Outline of Final Research Achievements

Purpose of this study is to develop a non-invasive blood oxygen saturation measurement method based on photo acoustic imaging technique. In photoacoustic imaging, pulsed light was irradiated to a biological tissue, and then ultrasound that was produced from blood inside biological tissue that absorbed pulsed light was measured. In this research, we developed both devise and algorithm for blood oxygen measurement, established animal model, and performed animal experiment to evaluate the accuracy. In addition, we discussed a new blood oxygen measurement technique that is not suffered from attenuation of light and ultrasound inside biological tissue, those were main cause of measurement error in existing photoacoustic technique.

Academic Significance and Societal Importance of the Research Achievements

血液酸素飽和度は,生体内におけるエネルギー産生に必要な酸素の供給状態を把握するうえで,重要な指標の一つです。採血した血液を分析する手法が標準的な計測法ですが,患者に対する負担が大きい問題があります。全身的な酸素供給状態を把握する目的では,採血を伴わないパルスオキシメータを使用可能ですが,局所的な酸素供給状態の把握する目的では依然として患者への負担を伴う手法がとられています。そこで本研究では,生体局所の血管内の血液酸素飽和度を体表から繰返し計測可能な技術を開発するための技術を開発し,評価しました。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Measurement of blood-oxygen saturation using a photoacoustic technique in the rabbit hypoxemia model2018

    • Author(s)
      Sei Kiguna,Fujita Masanori,Hirasawa Takeshi,Okawa Shimpei,Kushibiki Toshihiro,Hidenori Sasa,Kenichi Furuya,Ishihara Miya
    • Journal Title

      Journal of Clinical Monitoring and Computing

      Volume: 6(1) Issue: 2 Pages: 1-4

    • DOI

      10.1007/s10877-018-0166-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spectral-differential-based unmixing for multispectral photoacoustic imaging2018

    • Author(s)
      Hirasawa Takeshi、Iwatate Ryu J.、Kamiya Mako、Okawa Shinpei、Fujita Masanori、Urano Yasuteru、Ishihara Miya
    • Journal Title

      Applied Optics

      Volume: 57 Issue: 10 Pages: 2383-2383

    • DOI

      10.1364/ao.57.002383

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multispectral photoacoustic imaging of tumours in mice injected with an enzyme-activatable photoacoustic probe2017

    • Author(s)
      Hirasawa T, Iwatate JR, Kamiya M, Okawa S, Urano Y, Ishihara M
    • Journal Title

      Journal of Optics

      Volume: 19 Issue: 1 Pages: 14002-14002

    • DOI

      10.1088/2040-8978/19/1/014002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Photoacoustic measurement technique for sensitive detection of contrast agents2019

    • Author(s)
      Takeshi Hirasawa, Shinpei Okawa, Kazuhiro Tsujita, Miya Ishihara
    • Organizer
      SPIE Photonics WEST BiOS 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 分子イメージングのための広帯域超音波センサを用いた光音響イメージングに関する検討2018

    • Author(s)
      平沢壮, 大川晋平, 辻田和宏, 神谷真子, 浦野泰照, 石原美弥
    • Organizer
      日本分子イメージング学会 第13回 学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Multispectral photoacoustic tomography for detection of small tumors inside biological tissues2018

    • Author(s)
      Hirasawa Takeshi、Okawa Shinpei、Tsujita Kazuhiro、Kushibiki Toshihiro、Fujita Masanori、Urano Yasuteru、Ishihara Miya
    • Organizer
      SPIE BiOS, 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dependence of photoacoustic signal generation characteristics on fluorescence quantum yields of small organic molecule based contrast agents2017

    • Author(s)
      Takeshi Hirasawa, Ryu J Iwatate, Mako Kamiya, Shinpei Okawa, Yasuteru Urano, Miya Ishihara
    • Organizer
      SPIE Photonics West Biomedical Optics, BiOS 2017
    • Place of Presentation
      San Francisco
    • Year and Date
      2017-01-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 光音響技術を用いた小動物イメージング法に関する検討2017

    • Author(s)
      平沢 壮、大川 晋平、辻田 和宏、櫛引 俊宏、藤田 真敬、浦野 泰照、石原 美弥
    • Organizer
      第38回日本レーザー医学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Comparison of photoacoustic signal generation characteristics of small organic molecules with various fluorescence quantum yield2017

    • Author(s)
      Takeshi Hirasawa, Ryu J Iwatate, Mako Kamiya, Yuta Ikeda, Shinpei Okawa, Yasuteru Urano, Miya Ishihara
    • Organizer
      RIEC International Workshop on Biomedical Optics 2017
    • Place of Presentation
      Sendai
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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