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Development of temperature controllable multi-gas plasma source and application for endoscopic hemostasis

Research Project

Project/Area Number 16K17536
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Plasma electronics
Research InstitutionTokyo Institute of Technology (2017)
Kobe University (2016)

Principal Investigator

Takamatsu Toshihiro  東京工業大学, 科学技術創成研究院, 研究員 (10734949)

Research Collaborator Azuma Takeshi  神戸大学, 大学院医学研究科消化器内科学分野, 教授 (60221040)
Okino Akitoshi  東京工業大学, 科学技術創成研究院未来産業技術研究所, 准教授 (60262276)
Ito Norihiko  鳥取大学, 農学部附属動物医療センター, 准教授 (80264654)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords低温プラズマ / 血液凝固 / 3Dプリンタ / 内視鏡 / 止血 / 3Dプリンター / 小型プラズマ源 / 大気圧低温プラズマ / 温度制御プラズマ
Outline of Final Research Achievements

In this study, hemostasis effect was investigated with various gas plasma and various gas temperature using temperature controllable multi-gas plasma source. In addition, small size plasma source which can introduce into endoscope port(I.D.=3.2 mm) was developed and the fundamental property was investigated.
As the result, it found that carbon dioxide plasma have merit in a practical way. And the hemostasis effect was higher when the plasma gas temperature was higher. The damage of plasma treatment was little in case of below 200 degree As plasma treatment in gastrointestinal tract, hemostasis was achieved about 90 s.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (29 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (24 results) (of which Int'l Joint Research: 14 results,  Invited: 2 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Investigation of blood coagulation effect of nonthermal multigas plasma jet in-vitro and in-vivo2017

    • Author(s)
      Nomura Yudai、Takamatsu Toshihiro、Kawano Hiroaki、Miyahara Hidekazu、Okino Akitoshi、Yoshida Masaru、Azuma Takeshi
    • Journal Title

      Journal of Surgical Research

      Volume: 219 Pages: 302-309

    • DOI

      10.1016/j.jss.2017.06.055

    • NAID

      120006733174

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of the Staphylococcus aureus Inactivation Process Induced by a Multigas Plasma Jet2016

    • Author(s)
      T. Takamatsu, H. Kawano, Y. Sasaki, K. Uehara, H. Miyahara, Y. Matsumura, A. Iwasawa, T. Azuma, A. Okino
    • Journal Title

      Current Microbiology

      Volume: 73 Issue: 6 Pages: 766-772

    • DOI

      10.1007/s00284-016-1125-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of low temperature plasma source by 3D printer for healthcare and medical application2016

    • Author(s)
      大田 尚作, 高松 利寛, 沖野 晃俊, 東 健
    • Journal Title

      Asian International Integrated Design Project-Asia Design Forum 2016 Conference Proceedings

      Volume: 1 Pages: 1-6

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] 医科・歯科応用に適した温度制御大気圧マルチガスプラズマの開発と各種応用展開2018

    • Author(s)
      沖野晃俊, 高松利寛, 柳川由紀, 光原一朗, 松村有里子, 岩澤篤郎, 大田尚作, 川田善正
    • Organizer
      平成29年度生体医歯工学共同研究拠点成果報告会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] CO2プラズマバブル水の殺菌メカニズム解明に向けた活性種測定2018

    • Author(s)
      末永 祐磨, 川野 浩明, 三宅 智子, 高松 利寛, 松村 有里子, 宮原 秀一, 岩澤 篤郎, 沖野 晃俊
    • Organizer
      平成29年度生体医歯工学共同研究拠点 成果報告会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 超音波併用プラズマバブリングを用いた眼科用器具の殺菌2018

    • Author(s)
      末永祐磨, 川野浩明, 高松利寛, 松村有里子, 宮原秀一, 岩澤篤郎, 伊藤典彦, 沖野晃俊
    • Organizer
      応用物理学会 春季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 温度制御マルチガスプラズマジェットの開発と液中殺菌への応用2017

    • Author(s)
      堂山英之, 川野浩明, 高松利寛, 松村有里子, 宮原秀一, 岩澤篤郎, 伊藤 典彦, 東 健, 沖野晃俊
    • Organizer
      第6回 電気学会東京支部神奈川支所研究発表会
    • Place of Presentation
      神奈川県
    • Year and Date
      2017-02-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 医療応用に向けた大気圧マルチガス低温プラズマ源の開発2017

    • Author(s)
      高松利寛, 川野浩明, 黒澤学, 大田尚作, 松村有里子, 岩澤篤郎, 宮原秀一, 沖野晃俊
    • Organizer
      マグネティックス/光・量子デバイス/フィジカルセンサ/マイクロマシン・センサシステム/バイオ・マイクロシステム合同研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 3Dプリンターを用いた内視鏡用CO2低温プラズマ止血装置の開発2017

    • Author(s)
      高松利寛, 川野浩明, 林悠太, 黒澤学, 迫智也, 宮原秀一, 沖野晃俊
    • Organizer
      Plasma Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of relationship between sterilization effect and reactive-species in CO2 plasma bubbled-up water2017

    • Author(s)
      Yuma Suenaga, Hiroaki Kawano, Tomoko Miyake, Toshihiro Takamatsu, Yuriko Matsumura, Hidekazu Miyahara, Atsuo Iwasawa, Akitoshi Okino.
    • Organizer
      Plasma conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influence of gas species in plasma bubbling sterilization2017

    • Author(s)
      Yuma Suenaga, Hiroaki Kawano, Tomoko Miyake, Toshihiro Takamatsu, Yuriko Matsumura, Hidekazu Miyahara, Atsuo Iwasawa, Akitoshi Okino.
    • Organizer
      The 2nd International Symposium on Biomedical Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of 3D printed mini plasma jet and application to endoscopic hemostasis2017

    • Author(s)
      Yuta Hayashi, Hiroaki Kawano, Yudai Nomura, Toshihiro Takamatsu, Yuriko Matsumura, hidekadzu miyahara, Syusaku Ota, Atsuo Iwasawa, AKITOSHI OKINO.
    • Organizer
      The 2nd International Symposium on Biomedical Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lifetime of bactericidal factor in CO2 plasma bubbled-up water2017

    • Author(s)
      Hiroaki Kawano, Yuta Hayashi, Tomoko Miyake, Jumpei Hosoda, Toshihiro Takamatsu, Yuriko Matsumura, hidekadzu miyahara, Atsuo Iwasawa, Takeshi Azuma, AKITOSHI OKINO.
    • Organizer
      23rd International Conference on Plasma Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of low temperature plasma jet created by 3D printer for gastrointestinal hemostasis2017

    • Author(s)
      Toshihiro Takamatsu, Yudai Nomura, Manabu Kurosawa, Hiroaki Kawano, Yuta Hayashi, hidekadzu miyahara, Syusaku Ota, AKITOSHI OKINO.
    • Organizer
      23rd International Conference on Plasma Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 常温大気圧プラズマバブリング法を用いた眼科用器具の殺菌2017

    • Author(s)
      高松利寛, 川野浩明, 岩澤篤郎, 松村有里子, 宮原秀一, 沖野晃俊, 東健, 伊藤典彦, 後藤浩
    • Organizer
      第54回日本眼感染症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 3D PRINTED MINI PLASMA JET: APPLICATION TO HEMOSTATIC TREATMENT FOR ENDOSCOPE2017

    • Author(s)
      Yuta Hayashi, Hiroaki Kawano, Yudai Nomura, Toshihiro Takamatsu, Hidekazu Miyahara, Syusaku Ota, Takeshi Azuma, Akitoshi Okino
    • Organizer
      The 44th International Conference on Plasma Science
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of relationship between plasma gas temperature and reactive species2016

    • Author(s)
      Hideyuki Doyama, Hiroaki Kawano, Toshihiro Takamatsu, Yuriko Matsumura, Hidekadzu Miyahara, Atsuo Iwasawa, Takeshi Azuma, Akitoshi Okino
    • Organizer
      69th Annual Gaseous Electronics Conference
    • Place of Presentation
      Germany
    • Year and Date
      2016-10-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] プラズマガス温度と殺菌に寄与する活性種の関係調査2016

    • Author(s)
      堂山英之, 川野浩明, 高松利寛, 松村有里子, 宮原秀一, 岩澤篤郎, 東健, 沖野晃俊
    • Organizer
      日本防菌防黴学会 第43回年次大会
    • Place of Presentation
      東京都
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
  • [Presentation] マルチガスプラズマバブリングによる表面付着菌の不活化2016

    • Author(s)
      細田順平, 菅原修馬, 川野浩明, 高松利寛, 松村有里子, 宮原秀一, 岩澤篤郎, 東健, 沖野晃俊
    • Organizer
      日本防菌防黴学会 第43回年次大会
    • Place of Presentation
      東京都
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 3Dプリンタを用いた内視鏡治療用小型低温プラズマジェットの開発2016

    • Author(s)
      林悠太, 川野浩明, 野村雄大, 高松利寛, 宮原秀一, 大田 尚作, 東健, 沖野晃俊
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Place of Presentation
      新潟県
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Plasma bubbling inactivation effect on floating and adhesive bacteria2016

    • Author(s)
      Shuma Sugawara, Hiroaki Kawano, Toshihiro Takamatsu, Yuriko Matsumura, Hidekadzu Miyahara, Atsuo Iwasawa, Akitoshi Okino
    • Organizer
      6th International Conference on Plasma Medicine
    • Place of Presentation
      Slovakia
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of atmospheric non-thermal plasma sources created by 3D printer for medical application2016

    • Author(s)
      T. Takamatsu, Y. Nomura, Hiroaki Kawano, H. Miyahara, A. Okino and T. Azuma
    • Organizer
      6th International Conference on Plasma Medicine
    • Place of Presentation
      Slovakia
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Investigation of blood coagulation effect of non-thermal multi-gas plasma jet on in vitro and in vivo for endoscopic use2016

    • Author(s)
      Y. Nomura, T. Takamatsu, H. Kawano, H. Miyahara, A. Okino and T. Azuma
    • Organizer
      6th International Conference on Plasma Medicine
    • Place of Presentation
      Slovakia
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Investigation of Bactericidal Factors in CO2 Plasma Bubbling2016

    • Author(s)
      Hiroaki Kawano, Toshihiro Takamatsu, Yuriko Matsumura, Hidekazu Miyahara, Atsuo Iwasawa, Takeshi Azuma, Akitoshi Okino
    • Organizer
      6th International Conference on Plasma Medicine
    • Place of Presentation
      Slovakia
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 吸光光度法を用いたプラズマガス温度と液中活性種の関係調査2016

    • Author(s)
      堂山英之, 川野浩明, 高松利寛, 松村有里子, 宮原秀一, 岩澤篤郎, 東健, 沖野晃俊
    • Organizer
      平成28年度 公益社団法人 日本分光学会 年次講演会
    • Place of Presentation
      東京都
    • Year and Date
      2016-05-24
    • Related Report
      2016 Research-status Report
  • [Presentation] INVESTIGATION OF HYDROPONIC CULTURE USING PLASMA BUBBLING2016

    • Author(s)
      Toshihiro Takamatsu, Hiroaki Kawano, Hidekazu Miyahara, Takeshi Azuma, Akitoshi Okino
    • Organizer
      1st International Workshop on Plasma Agriculture
    • Place of Presentation
      USA
    • Year and Date
      2016-05-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measurement of reactive species in various gas plasma bubbled-up water for hydroponic culture2016

    • Author(s)
      Hiroaki Kawano, Toshihiro Takamatsu, Yuriko Matsumura, Hidekazu Miyahara, Atsuo Iwasawa, Takeshi Azuma, Akitoshi Okino
    • Organizer
      1st International Workshop on Plasma Agriculture
    • Place of Presentation
      USA
    • Year and Date
      2016-05-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] プラズマ産業応用技術2017

    • Author(s)
      大久保雅章
    • Total Pages
      321
    • Publisher
      シーエムシー出版
    • ISBN
      9784781312569
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 組織の把持と組織へのプラズマ照射とを可能にするエンドエフェクタおよびそのエンドエフェクタを備える内視鏡システム2018

    • Inventor(s)
      沖野晃俊,宮原秀一,川野浩明,林悠太,末永祐磨,高松利寛,黒澤学
    • Industrial Property Rights Holder
      沖野晃俊,宮原秀一,川野浩明,林悠太,末永祐磨,高松利寛,黒澤学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-057947
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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