Development of a novel method to generate nitrogen-centered radical species and its application to amination reactions
| Project/Area Number |
16K17868
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 超原子価ヨウ素 / ヨウ素 / アミノ化 / ラジカル / 有機化学 / 合成化学 |
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| Outline of Final Research Achievements |
In the presence of a metal catalyst, the amination of a C－H bond of aromatic compounds by a nitrogen-centered radical species generated from a hypervalent iodine reagent containing a phthalimidate proceeded to afford aniline derivatives albeit in low yield. In addition, an amination of enol silyl ether derived from various ketones proceeded effectively to provide α-aminated ketones in good yields. These results demonstrate a novel reactivity of hypervalent iodine reagents containing a phthalimidate.
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Report
(3 results)
Research Products
(26 results)
