Research on the cortical network for source memory in primates

• Project/Area Number: 16K18367
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Juntendo University
• Principal Investigator: Osada Takahiro 順天堂大学, 医学部, 准教授 (00456104)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 機能的磁気共鳴画像法 / 前頭葉 / 記憶 / 霊長類 / 神経活動不活性化 / fMRI / マカクサル / 出典記憶 / 神経活動不活化 / 光遺伝学 / 前頭前野

Outline of Final Research Achievements

We aimed to reveal the role of the frontal area in the cortical network for temporal contextual memory. By intervention to the frontal area detected in functional magnetic resonance imaging (fMRI), impairment in the task performance was observed. Furthermore, we applied this combined intervention method to other cognitive functions: response inhibition and metamemory.

Academic Significance and Societal Importance of the Research Achievements

本研究は、fMRIにより同定された脳領域・ネットワークに対し、介入手法を組み合わせ、(1) 時間的文脈での出典記憶に関わる前頭葉の役割、(2) 反応抑制に関わる大脳ネットワーク、(3) メタ記憶に関わる大脳ネットワークについて明らかにした。これらは、記憶想起に関わる大脳ネットワークの作動原理など、さまざまな認知機能の関わる神経機構の解明につながると考えられる。また、これらの成果は、高次認知機能脳障害の診断や治療法の確立につながることが期待される。

Research Products

• [Journal Article] An Essential Role of the Intraparietal Sulcus in Response Inhibition Predicted by Parcellation-Based Network. (2019)
  • Author(s): Osada T, Ohta S, Ogawa A, Tanaka M, Suda A, Kamagata K, Hori M, Aoki S, Shimo Y, Hattori N, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S.
  • Journal Title: J Neurosci. Volume: 39 Issue: 13 Pages: 2509-2521
  • DOI: 10.1523/jneurosci.2244-18.2019
  • Peer Reviewed / Open Access
• [Journal Article] Striatal subdivisions that coherently interact with multiple cerebrocortical networks (2018)
  • Author(s): Ogawa A†, Osada T†, Tanaka M, Hori M, Aoki S, Nikolaidis A, Milham MP, Konishi S († equal contribution)
  • Journal Title: Human Brain Mapping Volume: 39 Issue: 11 Pages: 4349-4359
  • DOI: 10.1002/hbm.24275
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Within-Subject Correlation Analysis to Detect Functional Areas Associated With Response Inhibition (2018)
  • Author(s): Yamasaki Tomoko、Ogawa Akitoshi、Osada Takahiro、Jimura Koji、Konishi Seiki
  • Journal Title: Frontiers in Human Neuroscience Volume: 12 Pages: 1-9
  • DOI: 10.3389/fnhum.2018.00208
  • Peer Reviewed / Open Access
• [Journal Article] Reversible silencing of the frontopolar cortex selectively impairs metacognitive judgment on non-experience in primates (2018)
  • Author(s): Miyamoto K, Setsuie R, Osada T, Miyashita Y
  • Journal Title: Neuron Volume: 97 Issue: 4 Pages: 980-987
  • DOI: 10.1016/j.neuron.2017.12.040
  • Peer Reviewed / Open Access
• [Journal Article] Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism (2017)
  • Author(s): Osada Takahiro、Suzuki Ruriko、Ogawa Akitoshi、Tanaka Masaki、Hori Masaaki、Aoki Shigeki、Tamura Yoshifumi、Watada Hirotaka、Kawamori Ryuzo、Konishi Seiki
  • Journal Title: NeuroImage Volume: 162 Pages: 1-12
  • DOI: 10.1016/j.neuroimage.2017.08.056
  • Peer Reviewed
• [Journal Article] Causal neural network of metamemory for retrospection in primates (2017)
  • Author(s): Miyamoto, K., Osada, T., Setsuie, R., Takeda, M., Tamura, K., Adachi, Y., and Miyashita, Y.
  • Journal Title: Science Volume: 355 Issue: 6321 Pages: 188-193
  • DOI: 10.1126/science.aal0162
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Lateral-medial dissociation in orbitofrontal cortex-hypothalamus connectivity (2016)
  • Author(s): Hirose S†, Osada T†, Ogawa A, Tanaka M, Wada H, Yoshizawa Y, Imai Y, Machida T, Akahane M, Shirouzu I, Konishi S († equal contribution)
  • Journal Title: Frontiers in Human Neuroscience Volume: 10 Pages: 244-244
  • DOI: 10.3389/fnhum.2016.00244
  • Peer Reviewed / Open Access
• [Presentation] Functional connectivity changes after rTMS used to detect plasticity decline associated with obesity (2019)
  • Author(s): Han S, Osada T, Ogawa A, Tanaka M, Hori M, Aoki S, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S
  • Organizer: FAOPS 2019
  • Int'l Joint Research
• [Presentation] Causally essential neural network for performing metacognitive judgement on experience and ignorance in primates (2018)
  • Author(s): Miyamoto K, Setsuie R, Osada T, Miyashita Y
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] Localisation and reversible silencing of metacognition networks for experienced and non-experienced events in primates (2018)
  • Author(s): Miyamoto K, Setsuie R, Osada T, Miyashita Y
  • Organizer: 11th FENS Forum of Neuroscience
  • Int'l Joint Research
• [Presentation] Striatal subdivisions interacting with multiple cerebrocortical networks (2018)
  • Author(s): 小川 昭利、長田 貴宏、田中 政輝、堀 正明、青木 茂樹、Aki Nikolaidis、Michael P Milham、小西 清貴
  • Organizer: 第2回 ヒト脳イメージング研究会
• [Presentation] Causal role of the frontopolar cortex for metacognitive judgement on non-experienced events in primates (2018)
  • Author(s): 宮本 健太郎、節家 理恵子、長田 貴宏、宮下保司
  • Organizer: 第41回 日本神経科学大会
• [Presentation] Areal parcellation and nucleus-level analysis of human hypothalamus using high-resolution fMRI (2017)
  • Author(s): Osada T, Suzuki R, Ogawa A, Tanaka M, Hori M, Aoki S, Tamura Y, Watada H, Kawamori R, Konishi S
  • Organizer: The 3rd Congress, International Academy of Sportology
  • Int'l Joint Research
• [Presentation] Connectivity-based parcellation of human hypothalamus revealed by high-resolution resting-state fMRI (2017)
  • Author(s): Osada T, Ogawa A, Tanaka M, Hori M, Aoki S, Konishi S
  • Organizer: 第40回 日本神経科学大会
  • Int'l Joint Research
• [Presentation] 高空間解像度fMRIによるヒト視床下部の機能的分割および核単位機能解析 (2017)
  • Author(s): 長田 貴宏、鈴木 瑠璃子、小川 昭利、田中 政輝、堀 正明、青木 茂樹、田村 好史、綿田裕孝、河盛 隆造、小西 清貴
  • Organizer: 第1回 ヒト脳イメージング研究会
• [Presentation] Parcellation of human hypothalamus using high-resolution resting-state fMRI (2016)
  • Author(s): Osada T, Ogawa A, Tanaka M, Hori M, Aoki S, Konishi S
  • Organizer: Neuroscience 2016（北米神経科学大会2016）
  • Place of Presentation: San Diego, USA
  • Int'l Joint Research
• [Presentation] Heterogeneity of orbitofrontal cortex with reference to hypothalamus (2016)
  • Author(s): Osada T, Hirose S, Ogawa A, Tanaka M, Wada H, Yoshizawa Y, Imai Y, Machida T, Akahane M, Shirouzu I, Konishi S
  • Organizer: 5th Biennial Conference on Resting State and Brain Connectivity 2016
  • Place of Presentation: Vienna, Austria
  • Int'l Joint Research
• [Presentation] Neuroanatomical basis of orbitofrontal-hypothalamic interaction revealed by areal parcellation (2016)
  • Author(s): Osada T, Hirose S, Ogawa A, Tanaka M, Wada H, Yoshizawa Y, Imai Y, Machida T, Akahane M, Shirouzu I, Konishi S
  • Organizer: OHBM 2016 Annual Meeting
  • Place of Presentation: Geneva, Switzerland
  • Int'l Joint Research
• [Presentation] Hierarchical prefrontal network arising from frontal pole area 10 during contextual memory retrieval in macaques (2016)
  • Author(s): Osada T, Adachi Y, Miyamoto K, Jimura K, Setsuie R, Watanabe T, Miyashita Y
  • Organizer: 第39回 日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] Orbitofrontal-hypothalamic functional interaction revealed by high-resolution resting-state fMRI (2016)
  • Author(s): Ogawa A, Osada T, Hirose S, Tanaka M, Wada H, Yoshizawa Y, Imai Y, Machida T, Akahane M, Shirouzu I, Konishi S
  • Organizer: 第39回 日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Remarks] 前頭極は未経験の出来事に対するメタ認知判断をつかさどる
  • URL: http://first.lifesciencedb.jp/archives/17897
• [Remarks] 「無知の知」はどのように生み出される？ - 前頭極が未知の出来事への自信の判断を司る
  • URL: https://academist-cf.com/journal/?p=7024