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Analysis of neural basis of mate-guarding behavior using medaka fish.

Research Project

Project/Area Number 16K18369
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionHokkaido University

Principal Investigator

Yokoi Saori  北海道大学, 薬学研究院, 助教 (10772048)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords配偶者防衛行動 / 不安定化ドメイン / バソプレシン / 配偶者選択 / 行動学 / 配偶者防衛 / メダカ / 神経基盤
Outline of Final Research Achievements

Mate-gurading behavior is induced by triadic relationships (two males and one female) and is observed in various animals. I previously found that vasopressin, which is one of neuropeptides, regulated mate-guarding behavior in medaka fish. Which neuron in the brain was necessary for inducing the behavior, however, is unknown. Therefore, I established the new methods in which I suppressed neural activity in some specific regions of the brain in a low molecular weight compound specific manner. In addition, we focused on female mating preference in medaka and revealed that long lasting mate-guarding increased the reproductive success of dominant males via disturbing visual interaction between the female and rival males.

Academic Significance and Societal Importance of the Research Achievements

低分子化合物の有無により時期特異的に遺伝子発現を制御する方法はマウスなどの哺乳類ではすでに確立されているが、同様の手法がメダカで使用できない、あるいは着目する行動によっては投与物質の性質的に問題がある、という問題があった。本研究で確立した方法はこうした問題をクリアしており、毒性も低いことが明らかになった。また、これまでメダカのメスが見知ったオスを配偶相手として選択する適応的意義は不明であったが、本結果により、配偶者防衛行動において優位となる、健康なオスの子孫を残すことができるというメリットがあると考えられた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2019 2018 2017 2016 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 7 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Highly efficient generation of knock-in transgenic medaka by CRISPR/Cas9-mediated genome engineering2018

    • Author(s)
      Watakabe Ikuko、Hashimoto Hisashi、Kimura Yukiko、Yokoi Saori、Naruse Kiyoshi、Higashijima Shin-ichi
    • Journal Title

      Zoological Letters

      Volume: 4 Issue: 1 Pages: 3-3

    • DOI

      10.1186/s40851-017-0086-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular basis of social competence in medaka fish2017

    • Author(s)
      Teruhiro Okuyama, Saori Yokoi, Hideaki Takeuchi
    • Journal Title

      Development, Growth, Differentiation

      Volume: 59 Issue: 4 Pages: 211-218

    • DOI

      10.1111/dgd.12359

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] メスの目移りを防ぐオスメダカ2017

    • Author(s)
      横井佐織
    • Journal Title

      化学と生物

      Volume: 55 Pages: 406-411

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mate-guarding behavior enhances male reproductive success via familiarization with mating partners in medaka fish.2016

    • Author(s)
      Yokoi S, Ansai S, Kinoshita M, Naruse K, Kamei Y, Young LJ, Okuyama T, Takeuchi H.
    • Journal Title

      Frontiers in Zoology

      Volume: 13 Issue: 1 Pages: 21-21

    • DOI

      10.1186/s12983-016-0152-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 親密度によって変化するメダカオスの社会行動発現2019

    • Author(s)
      横井 佐織
    • Organizer
      第13回バイオイメージングフォーラム重点共同利用合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Analysis of molecular basis underlying decision making according to social familiarity2018

    • Author(s)
      Saori Yokoi
    • Organizer
      4th Strategic Meeting for Medaka Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] メダカメスの配偶者選択を左右する、オスの配偶者防衛におけるバソトシンの役割2017

    • Author(s)
      *横井佐織、安齋賢、木下政人、成瀬清、亀井保博、Larry J. Young、奥山輝大、竹内秀明
    • Organizer
      第26回 日本行動神経内分泌研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Analysis of molecular basis underlying decision making according to social familiarity in small fish, medaka2017

    • Author(s)
      Saori Yokoi, Satoshi Ansai, Yasuhiro Kamei, Masato Kinoshita, Yoshihito Taniguchi, Larry J. Young, Teruhiro Okuyama, Takeo Kubo, Kiyoshi Naruse, Hideaki Takeuchi
    • Organizer
      IBNS 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 親密度依存の意思決定機構の分子基盤解析2017

    • Author(s)
      横井佐織, 安齋賢, 亀井保博, 木下政人, 谷口善仁, Larry J. Young, 奥山輝大, 久保健雄, 成瀬清, 竹内秀明
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] メダカにおける、社会関係の認知に基づく行動決定2017

    • Author(s)
      横井佐織,奥山輝大,亀井保博,谷口善仁,安齋賢,木下政人,成瀬清,竹内秀明
    • Organizer
      行動2017
    • Related Report
      2017 Research-status Report
  • [Presentation] メダカを用いた、配偶者防衛行動の分子神経基盤解析2017

    • Author(s)
      横井佐織
    • Organizer
      分子生物学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] メダカメスの配偶者選択を左右する、オスの配偶者防衛におけるバソトシンの役割2016

    • Author(s)
      横井佐織, 安齋賢, 木下政人, 成瀬清, 亀井保博, Larry J Young, 奥山輝大, 竹内秀明
    • Organizer
      第39回分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] メダカのバソトシンイソトシンシステム2016

    • Author(s)
      横井佐織
    • Organizer
      第87回日本動物学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] メダカオスの配偶者防衛がメスの配偶者選択にもたらす影響2016

    • Author(s)
      横井佐織, 安齋賢, 木下政人, 成瀬清, 亀井保博, Larry J Young, 奥山輝大, 竹内秀明
    • Organizer
      第35回 日本動物行動学会
    • Place of Presentation
      新潟大学(新潟県新潟市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report
  • [Presentation] Vasotocin system regulates mate-guarding behavior in medaka fish2016

    • Author(s)
      Saori Yokoi
    • Organizer
      第38回日本比較生理生化学会
    • Place of Presentation
      玉川大学(東京都町田市)
    • Year and Date
      2016-09-02
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Persistent mate - guarding enhances male reproductive success via familiarization with the female in medaka fish2016

    • Author(s)
      Saori Yokoi, Satoshi Ansai, Masato Kinoshita, Kiyoshi Naruse, Yasuhiro Kamei, Larry J Young, Teruhiro Okuyama Hideaki Takeuchi
    • Organizer
      第22回小型魚類研究会
    • Place of Presentation
      岡崎カンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2016-08-20
    • Related Report
      2016 Research-status Report
  • [Presentation] An essential role of vasotocin with mate-guarding behavior and an effect of mate-guarding on female mating preference in medaka2016

    • Author(s)
      Saori Yokoi, Satoshi Ansai, Masato Kinoshita, Kiyoshi Naruse, Yasuhiro Kamei, Larry J Young, Teruhiro Okuyama Hideaki Takeuchi
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Book] めだかの学校2018

    • Author(s)
      宗宮弘明、足立守、野崎ますみ、成瀬清
    • Total Pages
      314
    • Publisher
      あるむ
    • ISBN
      9784863331334
    • Related Report
      2017 Research-status Report
  • [Remarks] メスの目移りを防ぐオスメダカ ~恋敵に奪われないための二重の戦略~

    • URL

      http://www.nibb.ac.jp/press/2016/06/02.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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