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Age-related alterations of adult neurogenesis and its modulation by chondroitin sulfate

Research Project

Project/Area Number 16K18379
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyushu University

Principal Investigator

Yamada Jun  九州大学, 医学研究院, 講師 (70582708)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords海馬 / 神経新生 / コンドロイチン硫酸 / 加齢 / ケタミン / ニッチ / 神経科学
Outline of Final Research Achievements

Throughout life, production of new neurons continues in the hippocampus of mammals including humans. Adult-generated granule cells play an importantrole in regulation of hippocampus-dependent cognitive functions and emotional behavior. In this study, we found the age‐related molecular changes of chondroitin sulfate proteoglycan and Cat-315 epitope in the mouse hippocampus. Our observations provide a new insight into how to counteract age-related cognitive decline via enhancement of adult hippocampal neurogenesis.

Academic Significance and Societal Importance of the Research Achievements

ヒトを含めて、海馬では新しいニューロンが常に産生され、これらの新生ニューロンは記憶や情動に重要な役割を果たしている。また、加齢に伴う新生ニューロンの減少は、高齢者の認知機能の低下に関わると考えられている。本研究では、海馬のニューロン新生に重要な因子として、細胞外基質としての糖鎖の存在を同定し、そのメカニズムついて明らかにした。細胞外基質の生産を制御する物質は、認知機能の改善につながる可能性があることを示唆するものである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 4 results) Presentation (10 results)

  • [Journal Article] Increased synthesis of chondroitin sulfate proteoglycan promotes adult hippocampal neurogenesis in response to enriched environment.2018

    • Author(s)
      Yamada, J., Nadanaka, S., Kitagawa, H., Takeuchi, K., and Jinno, S.
    • Journal Title

      J. Neurosci.

      Volume: 38 Issue: 39 Pages: 8496-8513

    • DOI

      10.1523/jneurosci.0632-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in expression of Cat-315 epitope of perineuronal nets during normal ageing, and its modulation by an open-channel NMDA receptor blocker, memantine.2017

    • Author(s)
      Yamada J, Ohgomori T, Jinno S
    • Journal Title

      J Comp Neurol

      Volume: 525 Issue: 9 Pages: 2035-2049

    • DOI

      10.1002/cne.24198

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Molecular heterogeneity of aggrecan-based perineuronal nets around five subclasses of parvalbumin-expressing neurons in the mouse hippocampus.2017

    • Author(s)
      Yamada J, Jinno S.
    • Journal Title

      J Comp Neurol.

      Volume: 525 Issue: 5 Pages: 1234-1249

    • DOI

      10.1002/cne.24132

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Aging of hippocampal neurogenesis and soy isoflavone.2016

    • Author(s)
      Yamada J, Jinno S.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 51 Pages: 83835-83836

    • DOI

      10.18632/oncotarget.13534

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ll type- and region-specific enhancement of adult hippocampal neurogenesis by daidzein in middle-aged female mice.2016

    • Author(s)
      Yamada J, Hatabe J, Tankyo K, Jinno S.
    • Journal Title

      Neuropharmacology

      Volume: 111 Pages: 92-106

    • DOI

      10.1016/j.neuropharm.2016.08.036

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 海馬のペリニューロナルネット様PSA-NCAMはCCKニューロン周囲に形成され、セロトニン伝達に関与する2019

    • Author(s)
      山田純、神野尚三
    • Organizer
      第124回日本解剖学会総会・全国学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Short-term ketamine administration increases the adult neurogenesis in the ventral hippocampus of mouse models for depression2018

    • Author(s)
      Jun Yamada, Shozo Jinno
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ケタミンの単回投与は腹側海馬における神経新生を促進する2018

    • Author(s)
      山田純、神野尚三
    • Organizer
      第74回日本解剖学会九州州支部学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腸内細菌叢の改変による成体海馬神経新生の制御2018

    • Author(s)
      山田純、吉田史章、神野尚三
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] マウス海馬のコレシストキニン陽性GABAニューロンにおけるPSA-NCAM付加PNNの選択的形成2017

    • Author(s)
      山田純、今野幸太郎、渡辺雅彦、神野尚三
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Role of perineuronal nets in the maturation of the septohippocampal pathway2017

    • Author(s)
      Jun Yamada, Shozo Jinno,
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 海馬神経新生ニッチとしてのコンドロイチン硫酸2017

    • Author(s)
      山田純、神野尚三
    • Organizer
      第39回神経組織培養研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] PSA-NCAM付加PNNはマウス海馬のCCKニューロンにサブクラス選択的に形成され、抗うつ薬の作用機転に関与する2017

    • Author(s)
      山田純、神野尚三
    • Organizer
      第73回日本解剖学会九州州支部学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Alterations in aggrecan expression in the mouse hippocampus by aging and memantine2016

    • Author(s)
      Jun Yamada, Shozo Jinno
    • Organizer
      第39回日本神経科学大会(Neuro2016)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 海馬新生新生ニッチとしてのコンドロイチン硫酸の可能性2016

    • Author(s)
      山田純、神野尚三
    • Organizer
      第72回日本解剖学会九州支部学術集会
    • Place of Presentation
      長崎大学
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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