| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
We have recently found CUL3-KCTD complex, one of the E3 ubiquitin ligase, as a novel angiogenic factor. In this study, we screened the substrate of CUL3-KCTD complex using wheat cell-free synthesized protein array, resulting in the successful identification of regulator of GTP-RhoA. Knockdown of CUL3 or KCTD led to severe anti-angiogenic phenotypes due to accumulation of the substrate in endothelial cells. These data suggested that CUL3-KCTD would tightly regulate the substrate protein which might play a crucial role for vascular elongation during angiogenesis.
|
