| Project/Area Number |
16K18432
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kobayashi Hiroki 国立研究開発法人理化学研究所, 吉田化学遺伝学研究室, 協力研究員 (30528683)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ワールブルグ効果 / 代謝 / ケミカルバイオロジー / がん代謝 |
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| Outline of Final Research Achievements |
The Warburg effect, a metabolic derangement in cancer cells resulting in increased glucose uptake and glycolysis, is considered as a malignant phenotype. However, the mechanism regulating the Warburg effect has remained elusive. We had identified a novel compound that inhibits the Warburg effect by phenotypic screening. In this study, we elucidated the mode of action of the compound by using metabolomic, biochemical and genetic approach. As a result, we identified the target molecule of the compound, and uncovered the mechanism regulating the balance between glycolysis and oxidative phosphorylation.
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