Identification of immunosuppressive factor in tumor microenvironment in patient with lung cancer
| Project/Area Number |
16K18463
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Research Collaborator |
Oka MIKIO 川崎医科大学, 医学部・呼吸器内科学, 教授 (40223995)
Kurose KOJI 川崎医科大学, 医学部・呼吸器内科学, 臨床助教 (30551139)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺がん / がん抗原 / 免疫療法 / 免疫チェックポイント分子 / 肺癌 / XAGE1 / PD-1 / TIM-3 / Galectin-9 / 免疫チェックポイント / 癌 / 免疫活性化 |
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| Outline of Final Research Achievements |
The effect of immunotherapy in lung cancer is still insufficient, and elucidation of new immunosuppressive mechanism is important. In this study, expression of PD-1 and TIM-3 on tumor-infiltrating T cells and expression of their ligands on tumor cells were examined and analyzed for correlation with survival. Expression of PD-L1 and galectin-9 and XAGE 1 antigens on tumor cells were independent prognostic factors of TNM classification (HR: 0.40, p = 0.01).
Based on the above results, the survival of patients with lung adenocarcinoma can be predicted by investigating the tumor microenvironment in detail. Furthermore, in addition to the PD-1 / PD-L1 pathway, the TIM-3 / galectin-9 pathway is also important in the tumor microenvironment and development of cancer immunotherapy that inhibits them is very important.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] NY-ESO-1 Protein Cancer Vaccine With Poly-ICLC and OK-432: Rapid and Strong Induction of NY-ESO-1-specific Immune Responses by Poly-ICLC2017
Author(s)
Takeoka T, Nagase H, Kurose K, Ohue Y, Yamasaki M, Takiguchi S, Sato E, Isobe M, Kanazawa T, Matsumoto M, Iwahori K, Kawashima A, Morimoto-Okazawa A, Nishikawa H, Oka M, Pan L, Venhaus R, Nakayama E, Mori M, Doki Y, Wada H.
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Journal Title
J Immunother
Volume: epub
Issue: 4
Pages: 140-147
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Survival of Lung Adenocarcinoma Patients Predicted from Expression of PD-L1, Galectin-9, and XAGE1 (GAGED2a) on Tumor Cells and Tumor-Infiltrating T Cells2016
Author(s)
Ohue Y, Kurose K, Nozawa R, Isobe M, Nishio Y, Tanaka T, Doki Y, Hori T, Fukuoka J, Oka M, Nakayama E.
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Journal Title
Cancer Immunol Res
Volume: 12
Pages: 1049-1060
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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