• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular analysis of effect of infection stress into the next generation

Research Project

Project/Area Number 16K18497
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Molecular biology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Yoshida Keisuke  国立研究開発法人理化学研究所, 開拓研究本部, 協力研究員 (80587452)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsエピジェネティクス / 自然免疫 / 精子 / Transgenerational effect / Transgenerational / 自然免疫ストレス / 感染ストレス / 遺伝学
Outline of Final Research Achievements

Recent reports indicate that paternal environmental stress affects phenotype in offspring beyond generation. In this study, I tried to reveal "whether paternal immune stress affects pathogenic resistance in offspring" using mice. Here, it's observed that amount of specific type of methylated histone was changed in mouse sperm by infection stress. Furthermore, offspring from father mouse which have infected exhibited increased gene expression of inflammation-related genes.

Academic Significance and Societal Importance of the Research Achievements

今回の結果から、父親の病原体感染ストレスが次世代個体の免疫細胞の活性化状態に影響を与える可能性が示唆された。観察された免疫細胞の活性化が、個体の長期的恒常性に対して有利・不利に働くかはまだ解析が必要だが、子供を持つ予定の父親が自身の病原体感染の子供への影響を留意する必要がある可能性が考えられた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Analysis for trans-generational inheritance of epigenetic change induced by pathogen infection via ATF72017

    • Author(s)
      Keisuke Yoshida, Toshio Maekawa, Shunsuke Ishii
    • Organizer
      72th Fujihara Seminar
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis for trans-generational inheritance of epigenetic change induced by pathogen infection via ATF72017

    • Author(s)
      Keisuke Yoshida
    • Organizer
      Innate immune Memory
    • Place of Presentation
      Hinxton (UK)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 次世代へと継承されるエピゲノム変化を制御するATF7の機能解析2016

    • Author(s)
      吉田圭介
    • Organizer
      第10回エピジェネティクス研究会年会
    • Place of Presentation
      千里ライフサイエンスセンター (大阪・千里中央)
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi