• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanisms of axon collateral formation by cell-intrinsic Dscam1-Dscam1 interactions

Research Project

Project/Area Number 16K18536
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cell biology
Research InstitutionThe University of Tokyo

Principal Investigator

Kise Yoshiaki  東京大学, 大学院理学系研究科(理学部), 特任助教 (70769611)

Research Collaborator Dietmar Schmucker  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords軸索分枝 / 軸索 / 分枝 / シグナル伝達
Outline of Final Research Achievements

This project aims to reveal molecular mechanisms of axon collateral formation controlled by cell-intrinsic Dscam-Dscam interactions. We have identified two cytoskeleton regulators which interact with Dscam biochemically. Loss-of-function and gain-of-function analysis have shown that these two molecules are required for axon collateral formation. Furthermore, epistasis and genetic analysis indicate that Dscam and these two molecules are in the same signaling pathway required for axon collateral formation.

Academic Significance and Societal Importance of the Research Achievements

軸索側枝形成には、既存の主軸索の特定の地点から軸索が新たに形成され、それぞれが異なる目的地へ投射される必要がある。申請者らは、(1)Dscamが軸索側枝形成のマスター因子であること、(2)Dscamシグナルの時空間制御が軸索側枝形成に必要であることをこれまでに見出してきた。本研究では、これまで不明だったDscamシグナルの分子機構を明らかにすることができた。本成果は、軸索側枝形成の分子機構の解明に大きく貢献するばかりでなく、損傷を負った軸索に対してDscamシグナルを時空間操作することによって軸索側枝の形成を誘導し、軸索を再生させることができる可能性を提示することができた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2016 Other

All Int'l Joint Research (4 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] VIB, University of Leuven(ベルギー)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Iowa State University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Leuven(Belgium)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] University of Leuven(Belgium)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation.2019

    • Author(s)
      Sachse SM, Lievens S, Ribeiro LF, Dascenco D, Masschaele D, Horre K, Misbaer A, Vanderroost N, De Smet AS, Salta E, Erfurth ML, Kise Y, Nebel S, Van Delm W, Plaisance S, Tavernier J, De Strooper B, De Wit J, Schmucker D.
    • Journal Title

      EMBO J

      Volume: 38 Issue: 6

    • DOI

      10.15252/embj.201899669

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Molecular signaling pathways regulating axon branching via Dscam12018

    • Author(s)
      Kise Y, Izadifar A, Schmucker D, Emoto K
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society in 2018 at Kobe
    • Related Report
      2018 Annual Research Report
  • [Presentation] Studying diversity and functions of clustered protocadherins in Xenopus tropicalis2016

    • Author(s)
      Zengjin Huang, Yoshiaki Kise, Changsheng Chen, Sun Wei, Emre Etlioglu, Maximilian Ulbrich, Wei Chen, Dietmar Schmucker
    • Organizer
      Cold Spring Harbor Laboratory Meeting on Axon guidance, Synapse formation & Regeneration
    • Place of Presentation
      Cold Spring Harbor (the USA)
    • Year and Date
      2016-09-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi