| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Plasmalogen (Pls), a major phospholipid in neuronal membranes, is specifically decreased in brains from patients with Alzheimer’s disease (AD). The present study investigated how Pls administration affects cognitive deficits and lipid composition in an animal model of AD. Pls administration improved both reference and working memory-related learning abilities. In lipid analysis, Pls administration increased levels of Pls species in the plasma, erythrocytes, and liver. In addition, Pls administration increased levels of DHA-Pls in the cerebral cortex. These levels of DHA-Pls in the cerebral cortex were correlated with working memory-related learning ability. Moreover, DHA-PlsEtn levels in the cerebral cortex showed positive correlations with those in the erythrocytes and liver. In summary, dietary PlsEtn, especially that with DHA, may ameliorate learning deficiencies in AD by altering lipid composition in the brain.
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