Development of photolabile protective group for nitrile groups and its application to photoinduced NO donor furoxan
| Project/Area Number |
16K18844
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 光反応 / カルバゾール / 光感受性保護基 / 光線力学療法 / ニトリル基 / 光化学 / ニトリル / 有機化学 |
|---|
| Outline of Final Research Achievements |
Light is a traceless external stimuli and light-driven organic reactions find a wide application in various areas. In this project we have succeeded in development of molecular design which enables photo-induced nitrile formation. This development is useful because nitrile is a common functional group in drugs and fuctional molecules. One potent application of this development is a prodrug which has no effect in dark but obtains a healing function upon photo-irradiation. This is so called photodynamic therapy.
|
Report
(3 results)
Research Products
(26 results)
