| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Conversion of amyloid-β (Aβ protein from a non-toxic monomer into the toxic aggregates is the possible pathogenic pathways in Alzheimer’s disease. Recent studies have suggested that lipid membranes play key roles in protein aggregation. However, the binding modes and the mechanisms of Aβ aggregation on lipid vesicles are not fully understood. Here, we prepared a size-controlled lipid nanoparticles in order to control the number of Aβ molecules on the lipid bilayer surfaces of the particles. We have found that the secondary structure and the aggregation propensity of Aβ depended on the size of nanoparticles, suggesting the formation of intermediate species in the aggregation pathway.
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