| Project/Area Number |
16K18897
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAITO Yoshinori 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (30441588)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 種内多様性 / メタボローム / 二次代謝産物 / 高等植物 / NMR |
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| Outline of Final Research Achievements |
Lavandula angustifolia and Ligularia vellerea growing in different area of Japan and China, respectively, were found to be intra-specifically diverse in their chemical constituents. Chemical composition of L. angustifolia and L. vellerea was grouped into 3 and 2 types, respectively, using NMR metabolomic analysis of their extracts. The ingredient corresponding to the first principal component was identified for each species. Variation in composition of antioxidative aromatic substances among the L. angustifolia individuals growing in different areas was also evaluated. Intra-specific diversity in Ligularia lamarum was found to be more complex than previously known with regard to its chemical composition, nucleotide sequences, and geographical distribution.
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