| Project/Area Number |
16K18898
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Kumamoto University |
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Principal Investigator |
Kato Hikaru 熊本大学, 大学院生命科学研究部(薬), 助教 (20547129)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨粗鬆症 / 破骨細胞 / 阻害剤 / インドールアルカロイド / 分化 / 天然物 / RANKL / 破骨細胞分化 / セスキテルペン / 天然物化学 / 破骨細胞の分化阻害 |
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| Outline of Final Research Achievements |
Osteoporosis is a disease in which bone mineral density decreases and bone fracture risk increases due to increased osteoclasts. In this study, the ultimate goal is to develop a therapeutic agent for osteoporosis, and we searched for natural candidate compounds for drugs. In the 2 year research period in which this study was conducted, 20 new compounds were isolated and we published as 5 articles. Many of the compounds obtained in this study inhibit the formation of osteoclasts. In addition, some of these compounds inhibit the formation of osteoclasts by a mechanism different from the existing therapeutic agents, so they can be expected to be used as a new therapeutic agent for osteoporosis.
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