| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
DNA damage and its accumulation are related to lifestyle-related disorders such as cancer so that materials possessing DNA damage inhibitory activity may be efficient to protect lifestyle-related disorders. The purpose of our study is to provide effective seeds for preventing lifestyle-related disorders. We screened the extracts of natural resources by comet assay to find several resources with the DNA damage inhibitory activity. Furthermore, forty-three compounds containing thirteen new compounds were isolated from ten samples. Their structures were elucidated by the analyses of spectral data. UV-induced DNA damage inhibitory activity of isolates was evaluated by comet assay. As a result, four compounds showed the activity.
|
