Searching for natural resources with DNA damage inhibitory activity by comet assay
| Project/Area Number |
16K18903
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Natural medicines
|
|---|
| Research Institution | Showa Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | コメットアッセイ / 天然資源 / DNA損傷 / 天然物化学 |
|---|
| Outline of Final Research Achievements |
DNA damage and its accumulation are related to lifestyle-related disorders such as cancer so that materials possessing DNA damage inhibitory activity may be efficient to protect lifestyle-related disorders. The purpose of our study is to provide effective seeds for preventing lifestyle-related disorders. We screened the extracts of natural resources by comet assay to find several resources with the DNA damage inhibitory activity. Furthermore, forty-three compounds containing thirteen new compounds were isolated from ten samples. Their structures were elucidated by the analyses of spectral data. UV-induced DNA damage inhibitory activity of isolates was evaluated by comet assay. As a result, four compounds showed the activity.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究により見いだしたDNA損傷抑制作用を有する天然資源および含有成分は、今後研究を進めることで、生活習慣病予防に有効な機能性食品、サプリメント、化学予防薬としての応用が期待でき、健康寿命の延伸によるQOLの向上に貢献できると考えている。
|
Report
(4 results)
Research Products
(15 results)
