| Project/Area Number |
16K18931
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Okayama University (2017)
Chiba University (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 個別適正化 / 薬物動態 / てんかん / 抗てんかん薬 / ラモトリギン / 個別化医療 / レベチラセタム / TDM / オーダーメイド医療 |
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| Outline of Final Research Achievements |
Lamotrigine (LTG) is widely used among newer antiepileptic drugs in pregnant women with epilepsy. LTG is metabolized via glucuronidation by UGT1A4, and the main metabolite, LTG-2N-glucuronide is excreted in urine. The present study demonstrated that LTG clearance was well correlated with plasma LTG-2N-glucuronide/LTG ratio. Since UGT1A4 expression was induced during pregnancy, plasma LTG-2N-glucuronide/LTG ratio might be useful in individualized therapy with LTG in pregnant women.
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