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Pharmacokinetics of new antiepileptic drugs and individualized therapy in pregnant women

Research Project

Project/Area Number 16K18931
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionOkayama University (2017)
Chiba University (2016)

Principal Investigator

FUJIYOSHI MASACHIKA  岡山大学, 医歯薬学総合研究科, 准教授 (50751921)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords個別適正化 / 薬物動態 / てんかん / 抗てんかん薬 / ラモトリギン / 個別化医療 / レベチラセタム / TDM / オーダーメイド医療
Outline of Final Research Achievements

Lamotrigine (LTG) is widely used among newer antiepileptic drugs in pregnant women with epilepsy. LTG is metabolized via glucuronidation by UGT1A4, and the main metabolite, LTG-2N-glucuronide is excreted in urine. The present study demonstrated that LTG clearance was well correlated with plasma LTG-2N-glucuronide/LTG ratio. Since UGT1A4 expression was induced during pregnancy, plasma LTG-2N-glucuronide/LTG ratio might be useful in individualized therapy with LTG in pregnant women.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] フェニトインの血中濃度が偽陰性を示す頻度の解析2018

    • Author(s)
      藤吉正哉、鈴木貴明、石井伊都子
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト血漿中ラモトリギンおよび主要代謝物の同時モニタリング2017

    • Author(s)
      藤吉正哉、鈴木貴明、石井伊都子
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] ARCHITECTによるフェニトイン血中濃度測定で偽陰性を示す頻度の解析2017

    • Author(s)
      藤吉正哉、鈴木貴明、石井伊都子
    • Organizer
      第27回日本医療薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト血漿中のラモトリギンとその主要代謝物の同時測定法の確立2016

    • Author(s)
      藤吉正哉、有吉範高、石井伊都子
    • Organizer
      第26回日本医療薬学会年会
    • Place of Presentation
      京都
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
  • [Remarks] 岡山大学薬学部疾患薬理制御科学分野ホームページ

    • URL

      http://www.pharm.okayama-u.ac.jp/lab/pmaphs/

    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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