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Mechanisms underlying drug-induced tubulointerstitial nephritis

Research Project

Project/Area Number 16K18939
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionKyoto University

Principal Investigator

Nakagawa Shunsaku  京都大学, 医学研究科, 助教 (50721916)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords尿細管間質性腎炎 / 抗菌薬 / NSAIDs / 腸内細菌叢 / 腸内細菌 / 薬剤性腎障害
Outline of Final Research Achievements

Drug-induced renal tubulointerstitial nephritis is characterized by inflammation in renal interstitium, which can cause chronic renal dysfunction and anemia. However, the mechanisms underlying pathogenesis of tubulointerstitial nephritis remained unclear. In this study, we aimed to elucidate the mechanism of drug-induced tubulointerstitial nephritis based on the concept that factors outside the kidneys are involved in the development of tubulointerstitial nephritis. Analysis focusing on antimicrobial drugs and intestinal bacterial flora demonstrated that the intestinal flora is involved in the development of drug-induced tubulointerstitial nephritis.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Identification of Biomarkers for Tubular Injury and Interstitial Fibrosis in Chronic Kidney Disease2017

    • Author(s)
      中川 俊作
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 137 Issue: 11 Pages: 1355-1360

    • DOI

      10.1248/yakushi.17-00150

    • NAID

      130006191261

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2017-11-01
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.2017

    • Author(s)
      Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS.
    • Journal Title

      J Clin Invest

      Volume: 127 Issue: 1 Pages: 321-334

    • DOI

      10.1172/jci87532

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Time-Dependent Structural Alteration of Rituximab Analyzed by LC/TOF-MS after a Systemic Administration to Rats.2017

    • Author(s)
      Otani Y, Yonezawa A, Tsuda M, Imai S, Ikemi Y, Nakagawa S, Omura T, Nakagawa T, Yano I, Matsubara K
    • Journal Title

      PLoS One

      Volume: 12 Issue: 1 Pages: e0169588-e0169588

    • DOI

      10.1371/journal.pone.0169588

    • NAID

      120005947202

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia.2017

    • Author(s)
      Nishikawa Y, Funakoshi T, Horimatsu T, Miyamoto S, Matsubara T, Yanagita M, Nakagawa S, Yonezawa A, Matsubara K, Muto M.
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 79 Issue: 3 Pages: 619-633

    • DOI

      10.1007/s00280-017-3249-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disruption of Slc52a3 gene causes neonatal lethality with riboflavin deficiency in mice2016

    • Author(s)
      Yoshimatsu H, Yonezawa A, Yamanishi K, Yao Y, Sugano K, Nakagawa S, Imai S, Omura T, Nakagawa T, Yano I, Masuda S, Inui K & Matsubara K
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 27557-27557

    • DOI

      10.1038/srep27557

    • NAID

      120005818230

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Long-term renal outcomes of cisplatin-induced nephropathy2018

    • Author(s)
      Mayuko Kurimura, Shunsaku Nakagawa, Shota Takao, Yuki Okuda, Misako Nakamura, Yuki Otani, Tomohiro Omura, Satoshi Imai, Atsushi Yonezawa, Takayuki Nakagawa, Kazuo Matsubara
    • Organizer
      ISN Frontiers Meetings
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 薬毒物による間質性腎炎の発症における腸内細菌叢の関与2017

    • Author(s)
      高尾翔太、中川俊作、栗村万由子、中村美沙子、大谷祐基、大村友博、今井哲司、米澤淳、中川貴之、松原和夫
    • Organizer
      医療薬学フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 慢性腎臓病に伴う尿細管障害および間質線維化の機序解明2016

    • Author(s)
      中川俊作、西原久美子、宮田仁美、新家遥、冨田恵理、 梶原望渡、松原雄、家原典之、五十嵐芳暢、山田弘、 深津敦司、柳田素子、増田智先、松原和夫
    • Organizer
      第66回日本薬学会近畿支部総会・大会
    • Place of Presentation
      鹿児島市民文化ホール、南日本新聞会館みなみホール、鹿児島サンロイヤルホテル
    • Year and Date
      2016-10-15
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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